Toxicology and risk assessment
A.A. 2024/2025
Obiettivi formativi
The course is aimed at providing the specific knowledge about toxicology and risk assessment applied to the cosmetic field. The course will highlight the principles of cellular toxicity about skin, skin annexes and eye toxicology in terms of irritation, allergies, hypersensitivity, also related to daily exposure. Potential harmful effects of both natural and synthetic chemical compounds, used in the skincare formulations, make-up, and cleaning products will be analysed. Furthermore, the course will describe the tests used to evaluate the toxicity of cosmetics ingredient and the process of cosmetics risk assessment, divided in three steps: the hazard identification, the dose-response, and the exposure assessment.
Risultati apprendimento attesi
At the end of the course the students will be able to:
- Describe with proper terminology the mechanisms of cell toxicity potentially induced by cosmetics;
- Describe the ingredients in cosmetics associated to their potentially toxic profile;
- Identify the most appropriate tests to be used to evaluate skin and eye toxicity;
- Describe the process of safety assessment process of cosmetic ingredients;
- Perform basic assays to evaluate cell toxicity and to interpret the results;
- Evaluate and analyse the risk assessment case studies.
- Describe with proper terminology the mechanisms of cell toxicity potentially induced by cosmetics;
- Describe the ingredients in cosmetics associated to their potentially toxic profile;
- Identify the most appropriate tests to be used to evaluate skin and eye toxicity;
- Describe the process of safety assessment process of cosmetic ingredients;
- Perform basic assays to evaluate cell toxicity and to interpret the results;
- Evaluate and analyse the risk assessment case studies.
Periodo: Secondo semestre
Corso singolo
Questo insegnamento non può essere seguito come corso singolo. Puoi trovare gli insegnamenti disponibili consultando il catalogo corsi singoli.
Programma e organizzazione didattica
Edizione unica
Responsabile
Periodo
Secondo semestre
Programma
· Introduction to skin and eye toxicology: fundamentals of dose and toxicity of substances
· Skin toxicokinetics: dermal and percutaneous absorption, distribution, metabolism, and excretion
· Skin toxicodynamics: local and systemic toxicity; chronic exposure and repeated-dose toxicity; mechanisms of cell toxicity; classification of toxic effects; irritation, corrosivity, skin sensitisation, genotoxicity, carcinogenicity, photo-induced toxicity; systemic toxicity, reproductive toxicity, and endocrine interference; toxicity in relation to age and skin features
· Toxicity of the main cosmetics ingredients, impurities, natural extracts
· In vitro and in vivo assays required for safety evaluation and toxicological profile of cosmetic ingredients and finished products; new approach methodologies; tests on human volunteers.
· Current national and international regulations on cosmetics;
· Safety assessment process:
o Hazard identification (NOAEL)
o Calculation of the exposure (SED)
o Risk characterization (MoS)
· The quantitative risk assessment (QRA);
· Integrated Approaches to Testing and Assessment (IATA);
· CMR substances (carcinogenic, mutagenic or toxic for reproduction) and cosmetic regulations.
· Skin toxicokinetics: dermal and percutaneous absorption, distribution, metabolism, and excretion
· Skin toxicodynamics: local and systemic toxicity; chronic exposure and repeated-dose toxicity; mechanisms of cell toxicity; classification of toxic effects; irritation, corrosivity, skin sensitisation, genotoxicity, carcinogenicity, photo-induced toxicity; systemic toxicity, reproductive toxicity, and endocrine interference; toxicity in relation to age and skin features
· Toxicity of the main cosmetics ingredients, impurities, natural extracts
· In vitro and in vivo assays required for safety evaluation and toxicological profile of cosmetic ingredients and finished products; new approach methodologies; tests on human volunteers.
· Current national and international regulations on cosmetics;
· Safety assessment process:
o Hazard identification (NOAEL)
o Calculation of the exposure (SED)
o Risk characterization (MoS)
· The quantitative risk assessment (QRA);
· Integrated Approaches to Testing and Assessment (IATA);
· CMR substances (carcinogenic, mutagenic or toxic for reproduction) and cosmetic regulations.
Prerequisiti
None
Metodi didattici
Frontal classes with slides, video support, and expert lessons. Laboratory experiences based on in vitro toxicity assays will be performed in the Toxicology module. In the Risk assessment part, the students will discuss case-studies and risk communication/management through power point presentations.
Materiale di riferimento
Slides presented during the classes, digital supplemental material, scientific papers (available on the ARIEL website).
Modalità di verifica dell’apprendimento e criteri di valutazione
The exam consists in a multiple-choice test with 16 questions in 1 hour: 2 points for every correct answer, 0 points for unanswered/not correct answer. The exam is passed with a minimal score of 18.
BIO/14 - FARMACOLOGIA - CFU: 6
Esercitazioni di laboratorio a posto singolo: 32 ore
Lezioni: 32 ore
Lezioni: 32 ore
Docente:
Galbiati Valentina
Siti didattici
Docente/i