Pharmacogenomics, clinical pharmacology, and orphan drugs

A.A. 2024/2025
7
Crediti massimi
56
Ore totali
SSD
BIO/14
Lingua
Inglese
Obiettivi formativi
The course addresses and translates into pharmacology what has been learned from biochemistry to pathophysiology with the final aim to give the pharmacological basis of applied pharmacology and therapeutics. More specifically, the first part of the course is focused on clinical pharmacology from principle of general pharmacology to pharmacokinetics and pharmacodynamics of synthetic and biotechnological drugs. In the second part, the course will cover the pharmacogenomics issues of how genes affect a person's response to drugs and how an orphan drug has been developed to treat rare medical conditions.
Each topic will be discussed in terms of pathophysiology and genetics of the disease, the mechanism of action of the used drugs and their efficacy and safety profiles.
Risultati apprendimento attesi
At the end of the course, the student must be able to demonstrate that she/he has understood the pharmacological basis and the rationale for tailoring a specific drug to a specific patient and to assess the benefit/risk ratio inherent to its use.
Corso singolo

Questo insegnamento può essere seguito come corso singolo.

Programma e organizzazione didattica

Edizione unica

Responsabile
Periodo
Secondo semestre

Programma
General principles - Pharmacokinetics: drug absorption, distribution, metabolism, elimination. Membrane Transporters and Drug Response. Drug interactions. Pharmacodynamics: Molecular Mechanisms of Drug Action
Pharmacogenetics and Pharmacogenomics Importance of pharmacogenetics in drug response. Principle of pharmacogenetics. Molecular mechanisms of genetic polymorphisms. Monogenic versus multigenic pharmacogenetic traits. Pharmacogenetic phenotypes. Candidate Gene Versus Genome-Wide Approaches.
Clinical pharmacology Pharmacogenetics and pharmacogenomics in clinical practice. Cardiovascular drugs. Anticancer drugs.
Orphan drugs Rationale to design and develop a drug for an orphan disease. Basic and clinical pharmacology of an orphan drug
Prerequisiti
not requested
Metodi didattici
oral teaching with slides
Frontal lessons
Recommended frequency
Materiale di riferimento
· Basic and Clinical Pharmacology 15/e (LANGE Basic Science) 2021
Bertram Katzung
· Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14e 2022
Laurence L. Brunton, Björn C. Knollman
Modalità di verifica dell’apprendimento e criteri di valutazione
Examination at once
Methods of assessing knowledge Oral examination
Vote Vote verbalized (from 1/30 to 30/30
Evaluation parameters: capability to properly organize the knowledge, critical reasoning on the topics discussed, quality of exposure
BIO/14 - FARMACOLOGIA - CFU: 7
Lezioni: 56 ore
Docente: Corsini Alberto
Docente/i
Ricevimento:
Previo appuntamento telefonico