Developmental biology and genetics
A.A. 2024/2025
Obiettivi formativi
The objective of the course is to provide a deep understanding of the of the genetic and molecular mechanisms controlling plant and animal development. By analyzing the experimental data presented in research papers and reviews from the iliterature, the students will acquire the capability to discuss developmental processes and to compare different model organisms.
Risultati apprendimento attesi
At the end of the course the student will
- gain a strong theoretical background in important genetic/molecular mechanisms controlling plant and animal development;
- learn various experimental approaches in different model organisms, including cutting-edge technologies.
- be able to critically evaluate experimental data.
- be able to present a developmental biology topic to a scientific audience (other students and researchers)
- gain a strong theoretical background in important genetic/molecular mechanisms controlling plant and animal development;
- learn various experimental approaches in different model organisms, including cutting-edge technologies.
- be able to critically evaluate experimental data.
- be able to present a developmental biology topic to a scientific audience (other students and researchers)
Periodo: Primo semestre
Modalità di valutazione: Esame
Giudizio di valutazione: voto verbalizzato in trentesimi
Corso singolo
Questo insegnamento può essere seguito come corso singolo.
Programma e organizzazione didattica
Edizione unica
Responsabile
Periodo
Primo semestre
Programma
The model organisms most commonly used in Developmental Genetics and Biology will be presented.
Differentiation and morphogenesis processes will be analyzed at a genetic and molecular level, in order to understand how cells of the same organism can differentiate into distinct cell types and organize into complex structures.
Significant examples of animal development and plant development will be discussed, with a particular emphasis on the zebrafish and Arabidobpsis model systems, respectively.
Major signaling pathways with multiple roles in developmental processes in animals as well as in human pathological conditions will be discussed. Emphasis will be given to the role of RNA localization and translation in development, starting from classical examples in Drosophila development and pointing to dysfunctional processes in human diseases.
An overview of the impact of microRNAs on animal developmental processes will be given, starting from their discovery in C.elegans and pointing to their relevance for human diseases. A particular emphasis will be given to the zebrafish model system and the various genetic tools, which have been used in this organism to study development and to model human diseases.
Examples of Plant developmental mechanisms will be discussed with the students. In particular the course will focus on genetic and molecular control of organogenesis. Furthermore, some example of developmental regulation mediated by long non-coding RNAs and microRNAs, at transcriptional and post-transcriptional level will be discussed.
Differentiation and morphogenesis processes will be analyzed at a genetic and molecular level, in order to understand how cells of the same organism can differentiate into distinct cell types and organize into complex structures.
Significant examples of animal development and plant development will be discussed, with a particular emphasis on the zebrafish and Arabidobpsis model systems, respectively.
Major signaling pathways with multiple roles in developmental processes in animals as well as in human pathological conditions will be discussed. Emphasis will be given to the role of RNA localization and translation in development, starting from classical examples in Drosophila development and pointing to dysfunctional processes in human diseases.
An overview of the impact of microRNAs on animal developmental processes will be given, starting from their discovery in C.elegans and pointing to their relevance for human diseases. A particular emphasis will be given to the zebrafish model system and the various genetic tools, which have been used in this organism to study development and to model human diseases.
Examples of Plant developmental mechanisms will be discussed with the students. In particular the course will focus on genetic and molecular control of organogenesis. Furthermore, some example of developmental regulation mediated by long non-coding RNAs and microRNAs, at transcriptional and post-transcriptional level will be discussed.
Prerequisiti
A good basic knowledge of genetics and molecular biology is required. Some knowledge of developmental biology is useful.
Metodi didattici
Lessons will be based on powerpoint presentations and interactive discussions. Students will be stimulated to critically analyze experimental data from original papers and draw conclusions. Experts in the field of developmental biology and genetics will be invited to cover specific aspects of the course.
Materiale di riferimento
Powerpoint presentations and lists of reference papers/book chapters will be made available through the Ariel website. Students with little previous knowledge of animal developmental biology are encouraged to use a basic textbook (like Scott F. Gilbert, Developmental biology, Sinauer Associates, Inc., 9th edition) as a starting reference point. Students without or with little knowledge of plant biology and development will get 5 updated reviews about the subject to implement their knowledge.
It is important to stress that the course is mainly based on recent scientific literature in the field (relevant original papers and review articles will be listed on the Ariel webpage).
It is important to stress that the course is mainly based on recent scientific literature in the field (relevant original papers and review articles will be listed on the Ariel webpage).
Modalità di verifica dell’apprendimento e criteri di valutazione
Students will undergo an oral examination for the animal and plant developmental biology and genetics
The oral examination will be based on the analysis of several slides from the power point presentations, as a starting point to assess the acquired knowledge on different aspects of the program and the ability to critically interpret experimental data as well as to make links between different topics and/or model systems.
A final mark will be given, taking into account the results achieved in both part of the exam.
The oral examination will be based on the analysis of several slides from the power point presentations, as a starting point to assess the acquired knowledge on different aspects of the program and the ability to critically interpret experimental data as well as to make links between different topics and/or model systems.
A final mark will be given, taking into account the results achieved in both part of the exam.
BIO/18 - GENETICA - CFU: 6
Lezioni: 48 ore
Docente/i
Ricevimento:
su richiesta via e-mail
Ricevimento:
previo appuntamento concordato via mail
III piano Torre A, Via Celoria 26