Advanced genomics and epigenomics

The course can be split into two separate modules. In the Epigenomics module, students will first learn the genetic and epigenetic mechanisms underlying the regulation of gene expression. Then, they will learn the most widely used genome-wide NGS-based assays for their characterization, like ChIP-Seq, BS-Seq, etc, as well as the respective bioinformatic analysis pipelines. In the Advanced Genomics module, further genome-wide assays will be presented, expanding those already introduced in the Genomics and Transcriptomics course of the first year.

At the end of the course, students will be able to know apply state of the art bioinformatic pipelines, and understand their results, for:

- Genome wide characterization of transcription regulation (DNA methylation, nucleosome positioning, histone modifications, chromatin interactions, transcription factor binding)
- Advanced methods for the characterization and quantification of transcriptomes in both eukaryotes and prokaryotes, including small RNAs
- Metagenomics analyses
- Evolutionary genomics