Pharmaceutical Sciences
Doctoral programme (PhD)
A.Y. 2024/2025
Study area
Science and Technology
PhD Coordinator
The doctoral programme is designed to train highly skilled doctors to work successfully in the industrial and academic fields, and in the sector of medicines and healthcare products. The training, which aims at providing advanced methodological knowledge and scientific content in the pharmaceutical sector, includes theory and research, both centred on the design, synthesis, development and control of new biologically active compounds, new pharmaceutical forms, special foods, cosmetics, biocides and medical devices, typical of the fields covered in the doctoral programme:
- Design and synthesis of biologically active compounds
- Pharmaceutical, biopharmaceutical and toxicological analysis
- Drug metabolism and pharmacokinetics
- Pharmaceutical technology and legislation
- Food chemistry and food supplements
- Fermentation chemistry and biotechnology
- Advanced synthetic methodologies
- Physico-chemical characterization of biologically active compounds
- Herbal drugs, botanicals and active ingredients of plant origin
- Statistical methods for experimental data processing
- Design and synthesis of biologically active compounds
- Pharmaceutical, biopharmaceutical and toxicological analysis
- Drug metabolism and pharmacokinetics
- Pharmaceutical technology and legislation
- Food chemistry and food supplements
- Fermentation chemistry and biotechnology
- Advanced synthetic methodologies
- Physico-chemical characterization of biologically active compounds
- Herbal drugs, botanicals and active ingredients of plant origin
- Statistical methods for experimental data processing
Classi di laurea magistrale - Classes of master's degree:
LM-6 Biologia,
LM-8 Biotecnologie industriali,
LM-9 Biotecnologie mediche, veterinarie e farmaceutiche,
LM-13 Farmacia e farmacia industriale,
LM-21 Ingegneria biomedica
LM-22 Ingegneria chimica,
LM-53 Scienza e ingegneria dei materiali,
LM-54 Scienze chimiche,
LM-61 Scienze della nutrizione umana,
LM-69 Scienze e tecnologie agrarie,
LM-70 Scienze e tecnologie alimentari,
LM-71 Scienze e tecnologie della chimica industriale.
LM-6 Biologia,
LM-8 Biotecnologie industriali,
LM-9 Biotecnologie mediche, veterinarie e farmaceutiche,
LM-13 Farmacia e farmacia industriale,
LM-21 Ingegneria biomedica
LM-22 Ingegneria chimica,
LM-53 Scienza e ingegneria dei materiali,
LM-54 Scienze chimiche,
LM-61 Scienze della nutrizione umana,
LM-69 Scienze e tecnologie agrarie,
LM-70 Scienze e tecnologie alimentari,
LM-71 Scienze e tecnologie della chimica industriale.
Dipartimento di Scienze farmaceutiche - Via Mangiagalli, 25 - Milano
- Main offices
Dipartimento di Scienze farmaceutiche - Via Mangiagalli, 25 - Milano - Degree course coordinator: Giulio Vistoli
[email protected] - Degree course website
https://dsf.ariel.ctu.unimi.it/v5/home/PreviewArea.aspx
| Title | Professor(s) |
|---|---|
| Plants, ethnobotanical, natural products and food: from characterization to application |
C. Lammi
F. Secundo (CNR)
|
| Design of films for drug administration | |
| Study of novel micro- and nanoparticulate drug delivery systems |
F. Secundo (CNR)
|
| Study and development of oral drug delivery systems for spatio-temporal control of release | |
| Development of patient-centric drug delivery systems | |
| Study and development of therapeutic systems for intra-organ release of drugs | |
| Study and development of systems for delivery of microorganisms to specific sites of the gastrointestinal tract | |
| Design and synthesis of non-natural amino acids, peptidomimetics and their exploitation for the preparation of complex molecular architectures finding applications in biology, chemistry and nanomaterials | |
| C-C and C-H bonds activation through the metal-catalysis as a sustainable process to access to bioactive heterocyclic systems |
S. Riva (CNR)
|
| Development and application of computational approaches for rational design of novel biologically active compounds, for the investigation of their mechanism of action and for the prediction of their ADME/Tox profile |
T. Giorgino (CNR)
|
| Application of analytical, bioanalytical and "omics" techniques in drug discovery and development (identification of disease targets and biomarkers; study of the biological effects of drug candidates and drug metabolism). (ex DM 630/2024) |
M. Chiari (CNR)
C. Lammi
(Fidia Farmaceutici S.p.A.)
|
| Design, synthesis and study of structure-activity relationships of new derivatives acting at G protein-coupled receptors or at ligand-operated ionic channels | |
| Design, synthesis, structural and biological characterization and SAR of compounds with antiproliferative or antimicrobial activity | |
| Stereotechnologies development in the preparation and characterization of chiral molecules of biological concern |
S. Riva (CNR)
E. Rossi
F. Secundo (CNR)
|
| Quantitative and functional proteomic in drug discovery and development. | |
| Synthesis and chemical-physical characterization of nucleic acids analogues, including Peptide Nucleic Acids (PNAs), and aggregates with applications in biology and/or in nanomaterials. | |
| Protein hydrolysates and biopeptides: production, biological activities, and their applications in biomedical, food and cosmetic areas. |
C. Lammi
F. Secundo (CNR)
|
| New chemotypes from natural substances: design, synthesis and biological characterization. |
S. Riva (CNR)
C. Lammi
|
| Biologically active lipids in drug discovery and development |
F. Secundo (CNR)
|
| Novel applied experimental models for the development of new therapeutic approaches in cardiovascular and pulmonary disease | |
| Development of novel multitarget compounds with anti-inflammatory activity and improved safety profile | |
| Repurposing of anti-inflammatory drugs | |
| Phage display and fusion antibodies approaches to screen new molecular targets in the treatment of human pandemic infections and new barrer penetrating enhancers. | |
| Hydrogels and biocompatible polymers for tissue regeneration and tumor resection | |
| Diagnostic labels |
M. Chiari (CNR)
|
| Hybrid materials for the delivery of small molecules and biomolecules | |
| Development of nanomaterials for the cryoconservation of tissues and organs. | |
| Design, synthesis and pharmacological investigation of light-regulated bioactive compounds. | |
| Development of click chemistry hydrogels with applications in biosensing. | |
| Self-assembly and chemical reactions in vitro and in vivo | |
| Development of targeted protein degraders for therapeutic applications | |
| Gender differences in the regulation of metabolism and inflammation: relevance for precision pharmacology | |
| Role of estrogen receptor and its signaling in the regulation of metabolism and inflammation: relevance to physiopathology |
L. Rizzello
|
| Fusion Antibody to eradicate pathogenic bacteria and fight antimicrobial resistance | |
| Synthesis and functionalization of heterocyclic scaffolds of biological interest through innovative catalytic approaches | |
| New sustainable approaches for the synthesis of molecules of potential pharmaceutical interest | |
| Design and development of new potential antinfective agents | |
| Design and development of new multitarget ligands as potential therapeutic agents or biological probes for metabolic disorders | |
| Analytical approaches to assess functional and toxicological profiles of cosmetic ingredients | |
| regulatory and market access aspects for innovative medicinal products | |
| Study and development of efficient and sustainable processes for the production of solid dosage forms | |
| Development of ultra-sentisitve biosensors based on micro-nano magnetic beads (ex DM 630/2024)
Requirements: knowledge of microarray tecnology; surface and micro/nano beads functionalization; experience in immunoassay development; knowledge of molecular biology techniques |
Laura Sola (CNR)
|
| Formulation, pharmacokinetic and metabolism profiles of small inhibitors of the heme oxygenase I enzyme endowed with marked anticancer activity (ex DM 630/2024) |
NAVITA s.r.l.
|
Courses list
November 2024
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Data Visualization, Advanced Analytics and Artificial Intelligence | 3 | 18 | English | |
February 2025
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Compulsory | ||||
| The Drug Discovery Process: Development of a Clinical Candidate | 4 | 21 | English | |
| The Drug Discovery Process: from Lead Optimization to the Clinical Candidate | 4 | 20 | English | |
| Optional | ||||
| Crystallography Meets Medicinal Chemistry: an Introductory Course | 2 | 10 | English | |
March 2025
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Innovative Approaches for the Characterization and Activity Assays of Phytochemicals and Their in Vivo Metabolites | 3 | 15 | English | |
| Sex and Gender Effects: Relevance for Drug Development and Precision Pharmacology | 2 | 10 | English | |
April 2025
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Hpc@unimi: Indaco for Drug Discovery and Development | 3 | 15 | English | |
| Pharmacoeconomics and Marked Access: Strategies and Applications | 2 | 10 | English | |
June 2025
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| The Drug Discovery Process: from Target to Lead Identification | 4 | 20 | English | |
September 2025
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Gene Therapy and Advanced Biotech Drugs | 2 | 10 | English | |
| Analytical Approaches in Forensic Toxicology | 3 | 15 | English | |
| Mass Spectrometry Applications in Drug Discovery | 3 | 15 | English | |
| Mass Spectrometry in Pharmaceutical Analysis: Theory and Practice of Spectra Interpretation | 2 | 10 | English | |
Enrolment
Places available: 9
Call for applications
Please refer to the call for admission test dates and contents, and how to register.
Application for admission: from 29/05/2024 to 27/06/2024
Application for matriculation: from 09/08/2024 to 31/10/2024
Attachments and documents
Following the programme of study
Contacts
Office and services for PhD students and companies