Molecular and Cellular Biology

Dottorati
Doctoral programme (PhD)
A.Y. 2022/2023
Study area
Science and Technology
Doctoral programme (PhD)
3
Years
Dipartimento di Bioscienze - Via Celoria, 26 - Milano
English
PhD Coordinator
The doctoral programme aims to:
- train scientific experts with excellent skills in the field of biomolecular sciences and biotechnology;
- promote a molecular approach to the study of complex biological problems in model organisms (prokaryotic and eukaryotic microorganisms, animals and plants);
- encourage collaboration between research institutes, advanced training schools and companies in the fields of biomolecular sciences and biotechnology;
- encourage internationalisation by promoting international scientific collaborations, involving foreign lecturers, recruiting postgraduate students from abroad, and organising co-tutored dissertations involving study periods abroad.
Training activities will be characterised by:
- a multidisciplinary approach;
- interactivity;
- links to the business world;
- internationalisation.
A key element of the programme is the direct involvement of doctoral students in experimental research activities. Students will work full-time on a research project, providing critical insight and suggestions, and thereby acquiring scientific and organisational independence.
Classi di laurea - Classes of master's degrees:

LM-6 Biologia,
LM-7 Biotecnologie agrarie,
LM-8 Biotecnologie industriali,
LM-9 Biotecnologie mediche, veterinarie e farmaceutiche,
LM-11 Conservazione e restauro dei beni culturali,
LM-13 Farmacia e farmacia industriale,
LM-17 Fisica,
LM-18 Informatica,
LM-21 Ingegneria biomedica,
LM-22 Ingegneria chimica,
LM-25 Ingegneria dell'automazione,
LM-31 Ingegneria gestionale,
LM-32 Ingegneria informatica,
LM-35 Ingegneria per l'ambiente e il territorio,
LM-40 Matematica,
LM-41 Medicina e chirurgia,
LM-42 Medicina veterinaria,
LM-44 Modellistica matematico-fisica per l'ingegneria,
LM-46 Odontoiatria e protesi dentaria,
LM-47 Organizzazione e gestione dei servizi per lo sport e le attività motorie,
LM-48 Pianificazione territoriale urbanistica e ambientale,
LM-51 Psicologia,
LM-52 Relazioni internazionali,
LM-53 Scienza e ingegneria dei materiali,
LM-54 Scienze chimiche,
LM-56 Scienze dell'economia,
LM-58 Scienze dell'universo,
LM-59 Scienze della comunicazione pubblica, d'impresa e pubblicità,
LM-60 Scienze della natura,
LM-61 Scienze della nutrizione umana,
LM-67 Scienze e tecniche delle attività motorie preventive e adattate,
LM-68 Scienze e tecniche dello sport,
LM-69 Scienze e tecnologie agrarie,
LM-70 Scienze e tecnologie alimentari,
LM-71 Scienze e tecnologie della chimica industriale,
LM-73 Scienze e tecnologie forestali ed ambientali,
LM-74 Scienze e tecnologie geologiche,
LM-75 Scienze e tecnologie per l'ambiente e il territorio,
LM-76 Scienze economiche per l'ambiente e la cultura,
LM-78 Scienze filosofiche,
LM-79 Scienze geofisiche,
LM-82 Scienze statistiche,
LM-86 Scienze zootecniche e tecnologie animali,
LM-91 Tecniche e metodi per la società dell'informazione,
LM-92 Teorie della comunicazione,
LM/SNT1 Scienze infermieristiche e ostetriche,
LM/SNT2 Scienze riabilitative delle professioni sanitarie,
LM/SNT3 Scienze delle professioni sanitarie tecniche,
LM/SNT4 Scienze delle professioni sanitarie della prevenzione
Dipartimento di Bioscienze - Via Celoria, 26 - Milano
Title Professor(s)
Manipulation of caveolin expression levels to improve membrane fragility in caveolinopathies and muscular dystrophies to prevent myocytes lost and the onset of arrhythmias
A. Barbuti
Biochemistry and molecular mechanisms of florigenic signal transduction from rice leaves to shoot apical meristems via innovative proteomic approaches and imaging techniques.
Translational control of T cell-tumor interaction
T cell polarization in the tumor microenvironment
Dissecting Transposable Elements transcription in human T lymphocytes in health and disease
Study of the role of plant Ca2 + transporters in the regulation of the Ca2 + signature generated in response to environmental stresses through in vitro biochemical and structural analyzes and molecular imaging
Biology of model phages for phage therapy against P.aeruginosa
Bacterial and parasite -omics, mathematical modelling of biological systems with particular attention to their evolution.
Inflammation and cardiac rhythm disorders
Computational structural biology of protien folding, misfolding and aggregation
Pathogenic mechanisms in neurodegeneration: interplay among microtubule cytoskeleton, RNA metabolism and protein aggregation.
Dissecting the role of the methylase SMYD3 in the modulation of different features of breast cancer stem cells, and its impact on metastasis formation in vivo.
Human stem cell-based approaches for the study of transcriptional and chromatin abnormalities of Huntington’s disease neurons
Identifying the cell-specific neurodevelopmental component of Huntington Disease in the striatum using combined single-cell RNA and ATAC sequencing
Identifying the cell-specific neurodevelopmental component of Huntington Disease in the cortex using combined single-cell RNA and ATAC sequencing
Development and application of bioinformatics tools and methods for the analysis, integration and interpretation of omics data in precision medicine
Food security: Innovative plant reproductive strategy in a chancing environmental condition.
Study of the role of second messengers in the perception and response of plants to environmental stresses using state of the art microscopy and genetically encoded biosensors.
Cellular and molecular effects of uremic toxins on the microvascular endothelium and its secretoma as well as on the absorbent intestinal epithelium. Characterization of the plasma proteome of patients with chronic kidney disease (CKD).
From cancer to neurodegeneration: zebrafish to investigate human diseases
Investigation of alternative splicing dysregulation in tumors.
Uncovering molecular regulators as well as signalling cascades involved in intercompartmental comunication that control seed development
Defining novel molecular and cellular mechanisms that promote angiogenesis in neovascular diseases
Molecular mechanisms controlling the growth of rice in response to environmental and hormonal stimuli
Functional dissection of the canonical and non-canonical interplay between noncoding RNAs and NFY transcription factor in human cancer
Genetic diversity, evolution and functional impact of structurally complex loci of the human genome associated with neurodevelopmental disorders
Molecular bases of DNA-binding and functional cooperativity of human Transcription Factors
Structure and functional studies of self-assembling multi-enzyme nanoparticles for continuous redox biocatalysis.
development and implementation of bioinformatics tools for genomics and transcriptomics
Functional Analysis of Genes Controlling Inflorescence Architecture in Arabidopsis and Rice
Regulation of gene expression linked to virulence and interaction with the host in model bacteria.
Studies on the role of alternative splicing isoforms in human tumors
Identification of new diagnostic and therapeutic strategies to counteract the expansion of cerebral tumors, particularly glioblastoma
Development of a liposome-based and nutrigenomic approach to silence the transcription factor Nfix in Muscular Dystrophy
Innovative medical treatments based on the understanding of ion channel gating principles
Studying the molecular mechanisms responsible for the maintenance of genome integrity and their connections to human pathologies
Integrated structural biology on transcription factors
Functional and molecular characterization of the interaction between pathogens and tissue infiltrating Th1/17 cells in chronic inflammatory diseases.
Development and application of bioinformatic methods for the genome-wide characterization of gene expression and its regulation
Profiling transcription at DNA breaks to tackle genome instability
Unravelling the role of chromatin remodellers in response to environmental stimuli
Protective role of anthocyanins in cell model systems and dietary treatments in mice
Breaking Gram-negative bacteria outer membrane permeability barrier as a strategy to develop next generation antibacterial drugs
The lysosomal amyloid aggregation of β2-microglobulin promotes Multiple myeloma progression: a molecular focus on this pro-cancer mechanism
Investigation on the role and extent of translational control in diseases as diverse as autoimmune and neurological disorders.
Study of smooth muscle functionality in clinically-relevant Drosophila melanogaster models of a rare visceral myopathy caused by the R257C mutation in actin G2
Development and implementation of cloud-oriented bioinformatic tools and workflows
Structural study of proteins involved in different human diseases: retromer complex (ALS); CD36 (cancer); chimeric protein engineered for gene therapy (MS)
Mario Milani (CNR)
Structural and functional characterization of proteins involved in human pathologies for drug design and development, maily: 1) RNA virus proteins; 2) pro-apoptotic protein complexes overexpressed in tumors
Eloise Mastrangelo (CNR)
Alpha-synuclein aggregation: modulators and impact on gut-brain axis (Ex DM 352/2022)
Large-scale druggability assessment of target libraries with artificial intelligence-based structure-sequence combined features
Eloise Mastrangelo (CNR)
Large-scale druggability assessment of target libraries with artificial intelligence-based structure-sequence combined features (Ex DM 352/2022)
Translational regulation of gene expression
New state-of-the-art imaging tools to study how crops adapt to environmental changes

Courses list

October 2022
Courses or activities Professor(s) ECTS Total hours Language
Compulsory
How to Write a Molecular and Cellular Paper
4 20 English
January 2023
Courses or activities Professor(s) ECTS Total hours Language
Optional
Biostatistics for Molecular and Cellular Biology
5 27 English
February 2023
Courses or activities Professor(s) ECTS Total hours Language
Compulsory
Molecular and Cellular Biology. Methods and Communication of Results
4 24 English
June 2023
Courses or activities Professor(s) ECTS Total hours Language
Optional
Host- Pathogen Interaction
3 18 English
Non-Coding Rna 2 12 English