Molecular and Cellular Biology

Dottorati
Doctoral programme (PhD)
A.Y. 2023/2024
Study area
Science and Technology
Doctoral programme (PhD)
3
Years
Dipartimento di Bioscienze - Via Celoria, 26 - Milano
English
PhD Coordinator
The doctoral programme aims to:
- train scientific experts with excellent skills in the field of biomolecular sciences and biotechnology;
- promote a molecular approach to the study of complex biological problems in model organisms (prokaryotic and eukaryotic microorganisms, animals and plants);
- encourage collaboration between research institutes, advanced training schools and companies in the fields of biomolecular sciences and biotechnology;
- encourage internationalisation by promoting international scientific collaborations, involving foreign lecturers, recruiting postgraduate students from abroad, and organising co-tutored dissertations involving study periods abroad.
Training activities will be characterised by:
- a multidisciplinary approach;
- interactivity;
- links to the business world;
- internationalisation.
A key element of the programme is the direct involvement of doctoral students in experimental research activities. Students will work full-time on a research project, providing critical insight and suggestions, and thereby acquiring scientific and organisational independence.
Classi di laurea - Classes of master's degrees:

LM-6 Biologia,
LM-7 Biotecnologie agrarie,
LM-8 Biotecnologie industriali,
LM-9 Biotecnologie mediche, veterinarie e farmaceutiche,
LM-11 Conservazione e restauro dei beni culturali,
LM-13 Farmacia e farmacia industriale,
LM-17 Fisica,
LM-18 Informatica,
LM-21 Ingegneria biomedica,
LM-22 Ingegneria chimica,
LM-25 Ingegneria dell'automazione,
LM-31 Ingegneria gestionale,
LM-32 Ingegneria informatica,
LM-35 Ingegneria per l'ambiente e il territorio,
LM-40 Matematica,
LM-41 Medicina e chirurgia,
LM-42 Medicina veterinaria,
LM-44 Modellistica matematico-fisica per l'ingegneria,
LM-46 Odontoiatria e protesi dentaria,
LM-47 Organizzazione e gestione dei servizi per lo sport e le attività motorie,
LM-48 Pianificazione territoriale urbanistica e ambientale,
LM-51 Psicologia,
LM-52 Relazioni internazionali,
LM-53 Scienza e ingegneria dei materiali,
LM-54 Scienze chimiche,
LM-56 Scienze dell'economia,
LM-58 Scienze dell'universo,
LM-59 Scienze della comunicazione pubblica, d'impresa e pubblicità,
LM-60 Scienze della natura,
LM-61 Scienze della nutrizione umana,
LM-67 Scienze e tecniche delle attività motorie preventive e adattate,
LM-68 Scienze e tecniche dello sport,
LM-69 Scienze e tecnologie agrarie,
LM-70 Scienze e tecnologie alimentari,
LM-71 Scienze e tecnologie della chimica industriale,
LM-73 Scienze e tecnologie forestali ed ambientali,
LM-74 Scienze e tecnologie geologiche,
LM-75 Scienze e tecnologie per l'ambiente e il territorio,
LM-76 Scienze economiche per l'ambiente e la cultura,
LM-78 Scienze filosofiche,
LM-79 Scienze geofisiche,
LM-82 Scienze statistiche,
LM-86 Scienze zootecniche e tecnologie animali,
LM-91 Tecniche e metodi per la società dell'informazione,
LM-92 Teorie della comunicazione,
LM/SNT1 Scienze infermieristiche e ostetriche,
LM/SNT2 Scienze riabilitative delle professioni sanitarie,
LM/SNT3 Scienze delle professioni sanitarie tecniche,
LM/SNT4 Scienze delle professioni sanitarie della prevenzione
Dipartimento di Bioscienze - Via Celoria, 26 - Milano
Title Professor(s)
Mitochondrial dysfunction in atrial fibrillation pathogenesis
Requirements: Basic knowledge of general and cellular physiology
A. Barbuti
Interactome studies on regulators of flower development in rice through advanced proteomics
Requirements: Basic knowledge of plant anatomy, molecular biology, biochemistry and microsccopy
Translational regulation of the tumor microenvironment
Requirements: Basic knowledge of biochemistry, molecular and cellular biology
Development of new strategies for plant protection against phytopathogens
Requirements: Basic knowledge of plant physiology and optical microscopy
Elucidating key steps of Pseudomonas aeruginosa infection by lytic phages for phage therapy
Requirements: Basic knowledge of microbiology, genetics and molecular biology
Study of the recovery from Flavescence doreè in grapevine infected by Candidatus Phytoplasma vitis in vineyards excluded from re-infection by S.titanus
Requirements: R coding
M. Moser (MACH)
Study of the molecular mechanisms involved in cardiac rhythm disorders induced by inflammation
Requirements: Basic knowledge of general and cellular physiology
Development and application of in-silico techniques to simulate concentration dependent self-assembly processes at high spatial and time resolution
Requirements: Basic knowledge of structural biology, biophysics and coding
Looking at the role of microtubule dysfunction and RNA metabolism in pathological alpha-synuclein aggregation
Requirements: Basic knowledge of cellular and molecular biology
Flourish or perish: pro-regenerative epigenetic programme to sustain axonal sprouting of peripheral nerves
Requirements: Basic knowledge of cellular and molecular biology
D. Cartelli (Besta)
A human stem cell platform for the identification of modifiers of CAG repeat in the gene causing Huntington’s Disease
Requirements: Basic knowledge of genetics, molecular and cellular biology
Development and application of bioinformatics methods for the analysis, integration and interpretation of omics data
Requirements: Basic knowledge of genetics and molecular biology
Adaptation and resilience to climate change of the reproductive mechanisms in higher plants
Requirements: Basic knowledge of genetics, molecular biology and plant development.
Basic knowledge of genetics - dominance/epistasis - familiarity with the Crispr-Cas9 system
Requirements: Basic knoledge of genetics - dominance/epistasis - familiarity with the Crispr-Cas9 system
Study of the molecular mechanisms involved in the propagation of systemic electrical and calcium signals in response to mechanical stimuli in plants
Requirements: Basic knowledge of plant physiology, transport physiology, signal transduction, role of second messengers, optical microscopy.
Cellular and molecular characterization of the role of membrane glycoprotein, vasorin, on vascular musculature to investigate a possible link between chronic kidney disease and propensity to the onset of cardiovascular diseases.
Requirements: Basic knowledge of cell biology, animal/human cell cultures, cellular and protein biochemistry
Modeling SMPX-linked hearing loss and distal myopathy in zebrafish
Requirements: Basic knowledge of molecular biology, cell biology, and animal developmental biology
Investigation of alternative splicing dysregulation in tumors.
Requirements: Basic knowledge of genetics, molecular biology and bioinformarics
Biodiversity studies for adaptation to climate change tollerance in rice
Requirements: Basic knowledge of plant biology, botany and molecular biology
Defining novel molecular and cellular mechanisms that promote angiogenesis in neovascular diseases
Requirements: Basic knowledge of biochemistry, cellular and molecular biology and physiology
Study of the molecular mechanisms controlling cardiovascular regenerative cell function in age-associated diseases
Requirements: Basic knowledge of biochemistry, cellular and molecular biology and physiology
G. Spinetti (Multimedica)
Role of mechanical forces during the floral transition of the rice shoot apical meristem
Requirements: Basic knowledge of plant anatomy and molecular biology
Functional analysis of dependency-associated non-coding RNAs to discover novel vulnerabilities of human cancer (ex DM 118/2023)
Requirements: Basic knowledge in genetics, epigenetics, molecular and cell biology
Adapting flowering time and floral meristem commitment in response to temperature increase in Arabidopsis thaliana and Brassica napus for yield improvement
Requirements: Basic knowledge of genetics and molecular biology
Functional Analysis of Genes Controlling Inflorescence Architecture in Rice for Yield Improvement
Requirements: Basic knowledge of genetics and molecular biology
Molecular characterization of the role of single bacterial species from a multi-strain formulation marketed as probiotics on the virulence of clinical isolates from bacterial prostatitis (ex DM 117/2023)
Requirements: Basic knowledge of general and molecular microbiology
Dissecting the role of the FAM46C/BCCIP complex in multiple myeloma
Requirements: Experience working in a tissue colture hood would be a plus
Molecular basis of DNA-binding and molecular cooperativity of human Transcription Factors
Requirements: Basic knowledge of biochmistry, molecular biology and bioinformatics
Towards diagnostic fingerprinting using new optical biosensor technologies
Requirements: Basic knowledge of biochemistry, optical technologies and data handling
The potential of ncRNA as biomarkers of cardiovascular diseases (ex DM 117/2023)
Requirements: Basic knowledge of molecular biology and bioinformatics
F. Martelli (PSD)
The Flaviviruses replication complex as a strategic target for antivirals development
Requirements: Basic knowledge of biochemistry and strcutural biology
E. Mastrangelo (CNR)
Metformin administration combining with transcranial stimulation as a novel therapy against glioblastoma
Requirements: Basic knowledge of physics, biochemistry, cellular and molecular biology and physiology
High-throughput screening to identify Nfix-modulators in Cancer and Muscular Dystrophies
Requirements: Basic knowledge of cell and molecular biology
New hybrid Proteins: novel tools to regulate neuroinflammation in Multiple Sclerosis
Requirements: Basic knowledge of biochemistry and strcutural biology
C. Milani (CNR)
Characterization of the relationship between G-quadruplex, 3D nuclear organization, and genome stability (ex DM 118/2023)
Requirements: Basic knowledge of genetics and molecular biology
Novel therapeutic approaches emerging from ion channels' structural studies
Requirements: Basic knowledege of membrane proteins and rudiments of molecular biology, bicohemistry and biophysics
Cryo-EM structural biology on transcription factors and on their interaction with DNA
Requirements: Basic knowledge of biochemistry and structural biology
Functional and molecular characterization of the interaction between bacterial pathogens and tissue infiltrating Th17 cell subsets in chronic inflammatory diseases.
Requirements: Basic knowledge of Immunology, Microbiology and molecular biology.
Profiling transcription at DNA breaks to tackle genome instability
Requirements: Basic knowledge of genetics and molecular biology
Unravelling the function of chromatin remodellers in response to environmental stresses
Requirements: Basic knowledge in genetics, epigenetics, molecular and cell biology
Peptide-based fungicides for a sustainable agriculture
Requirements: Basic knowledge of Genetics, Molecular biology and Biochemistry
Role of flavonoids in the prevention of inflammation and related molecular mechanisms
Requirements: Basic knowledge of genetics and molecular biology
Manipulating the outer membrane permeability of Gram-negative bacteria as a strategy to develop of next generation antibacterial drugs (ex DM 118/2023)
Requirements: Basic knowledge of microbiology, bacterial genetics and molecular biology
Verso la comprensione del ruolo molecolare della N-glicosilazione nella aggregazione di catene leggere kappa in pazienti affetti da amiloidosi AL
Requirements: Basic knowledge of biochemistry and strcutural biology
Identification of novel bacterial virulence factors and inflammation determinants associated with persistent lung infections in cystic fibrosis patients
Requirements: Basic knowledge of general and molecular microbiology
Mechanism of action and (self)regulation of human MICAL1, the multidomain flavoenzyme involved in the control of actin cytoskleton dynamics in health and disease
Requirements: Basic knowlwedge of biochiemistry and molecula biology
Characterization of human histone (lysine) deacetylases as drug targets
Requirements: Basic knowlwedge of biochiemistry and molecula biology
A Drosophila model of Type B Kufs/CLN13 disease to study pathogenesis and Cathepsin F function
Requirements: Basic knowledge of cell and molecular biology
An in vivo model of intractable R257C-ACTG2 Visceral Myopathy to study pathogenesis and to identify new disease targets
Requirements: Basic knowledge of cell and molecular biology
Seed biology traits governed by heterosis and their relation to environmental stresses (ex DM 117/2023)
Biochemical and structural characterisation of toxic protein aggregates from cats affected by AA amyloidosis to design future treatments (ex DM 117/2023)
Epigenetic and metabolic targeting of skeletal muscle, during aging (ex DM 118/2023)

Courses list

November 2023
Courses or activities Professor(s) ECTS Total hours Language
Optional
Protein Structure Prediction and Design: How to Use Alphafold and Other Ai Methods for Research 2 12 English
January 2024
Courses or activities Professor(s) ECTS Total hours Language
Compulsory
Biostatistics for Molecular and Cellular Biology
5 27 English
February 2024
Courses or activities Professor(s) ECTS Total hours Language
Compulsory
Molecular and Cellular Biology. Methods and Communication of Results
4 24 English
June 2024
Courses or activities Professor(s) ECTS Total hours Language
Optional
Big-Data in Molecular Biology: from Experimental Design to Molecular Function 2 12 English
July 2024
Courses or activities Professor(s) ECTS Total hours Language
Optional
Disease Modeling in Molecular Biomedicine: Focus On Excitable Systems 2 12 English

Enrolment

Places available: 21

Call for applications

Please refer to the call for admission test dates and contents, and how to register.

Application for admission: from 27/06/2023 to 26/07/2023

Application for matriculation: from 25/09/2023 to 01/10/2023

Read the Call


Attachments and documents

Attachments to the call

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Qualifications assessment criteria

Scores and exam schedule