National Phd in Systems Medicine

Dottorati
Doctoral programme (PhD)
A.Y. 2024/2025
Study area
Medicine and Healthcare
Doctoral programme (PhD)
4
Years
Dipartimento di Oncologia ed Ematologia-Oncologia - Via Adamello, 16 - 20139 MILANO (MI)
English
PhD Coordinator
The recent progresses made in the fields of genetics and genomic sciences have triggered a big change, which is leading classical medicine to transform itself into the so-called Precision Medicine, based on the acquisition and integration of enormous quantities of quantitative molecular data and their exploitation for a personalized definition of the disease and of his targeted therapy. Precision Medicine has changed the way in which the cellular and molecular mechanisms of the disease are investigated. It uses technological platforms to produce a big amount of information, which allow to highlight and quantify the heterogeneous nature of diseases and the phenotypic variability associated with individuals. Precision Medicine will totally change the approach to treatment not only for therapy, but also for diagnosis and prevention. Therefore, the transition to Precision Medicine requires professionals with new skills and multi-disciplinary training.
The PhD in Systems Medicine aims to provide doctors and scientists with interdisciplinary theoretical and technological training in biomedical sciences to be applied to the problems of precision medicine, with the aim of training professionals capable of dealing with technological strategies and highly complex therapeutics with a multidisciplinary approach.
Tutte le classi di laurea magistrale - All classes master's degree
Dipartimento di Oncologia ed Ematologia-Oncologia - Via Adamello, 16 - 20139 MILANO (MI)
Title Professor(s)
Unraveling oncogene-induced dependencies in MYC-driven tumors: molecular mechanisms and therapeutic development.
Curriculum: Molecular Oncology
B. Amati (IEO)
MYC-regulated genes: their function in growth control, tumorigenesis and as potential therapeutic targets
Curriculum: Molecular Oncology
B. Amati (IEO)
Oncogenes transcription and cancer
Curriculum: Molecular Oncology
B. Amati (IEO)
BACE2 shapes tumor microenvironment
Curriculum: Molecular Oncology
A. Bachi (IFOM)
Functional proteomics
Curriculum: Molecular Oncology
A. Bachi (IFOM)
Genomics of Cancer and Targeted Therapies
Curriculum: Molecular Oncology
A. Bardelli UNITO
Defining LINE1-transcript dynamics in tumor-infiltrating lymphocytes at single cell resolution
Curriculum: Computational Biology
Dissecting the epigenetic role of Transposable Elements in tumor infiltrating lymphocytes
Curriculum: Molecular Oncology
MS-based proteomics and multi-omics to characterise the role of epigenetic enzymes in cancer heterogeneity, plasticity, and response to treatment
Curriculum: Molecular Oncology
Multi -OMIC integration of epigenomics and proteomics data from cancer clinical samples, for epigenetic biomarkers identification and dissection of novel targets
Curriculum: Molecular Oncology
Identifying the functional and physical network of the cohesin loader Scc2/NIPBL in genome integrity;
Curriculum: Molecular Oncology
D. Branzei (IFOM)
DNA repair mechanisms
Curriculum: Molecular Oncology
D. Branzei (IFOM)
Adaptation to hypoxia and EMT
Curriculum: Molecular Oncology
F. Buffa (IFOM)
Artificial intelligence & System Biology
Curriculum: Molecular Oncology
F. Buffa (IFOM)
Molecular Mechanisms of RNA editing machines
Curriculum: Molecular Oncology
A. Casañal (HT)
Molecular Mechanisms of RNA Editing Macromolecular Complexes
Curriculum: Molecular Oncology
A. Casañal (HT)
Integrative structural biology of thyroid hormone regulation in health and disease
Curriculum: Molecular Oncology
F. Coscia (HT)
Structural and functional characterization of thyroid trafficking factors
Curriculum: Molecular Oncology
F. Coscia (HT)
Mastering the Survival Secrets of Cancer: Unveiling and Targeting the Hidden Mechanisms Behind Cancer Therapy Resistance and Cellular Endurance
Curriculum: Molecular Oncology
Decoding the Mysteries of Cancer: Harnessing the Power of Genomics, Deep Learning, and Bioinformatics to Decipher the Complex Interplay of Protein Interactions and DNA Repair in Cancer Cells
Curriculum: computational biology
The role of DNA damage-induced non coding RNA in cancer and aging
Curriculum: Molecular Oncology
F. d'Adda di Fagagna (IFOM)
Impact of telomere dysfunction on immune system deregulation
Curriculum: Molecular Oncology
F. d'Adda di Fagagna (IFOM)
Systems biology of glial cell evolution, aging, and rejuvenation.
Curriculum: computational biology
J. Davila-Velderrain (HT)
Genomic basis of bioelectricity in evolution, development, and disease.
Curriculum: computational biology
J. Davila-Velderrain (HT)
Investigating telomere loss during replication
Curriculum: Molecular Oncology
Y. Doksani (IFOM)
Replication Stress Response
Curriculum: Molecular Oncology
Y. Doksani (IFOM)
Assessing the allelic landscape of T cell deficiency and dysregulation
Curriculum: computational biology
C. Dominguez Conde (HT)
Dissecting immune developmental trajectories with single-cell genomics
Curriculum: computational Biology
C. Dominguez Conde (HT)
Organization of Neuronal Nucleoli In Situ
Curriculum: Molecular Oncology
P. Erdmann (HT)
Understanding Biomolecular Condensation in Neurodegenerative Disease Models from In Vitro to Tissue
Curriculum: Molecular Oncology
P. Erdmann (HT)
Mechanobiology of Glioblastoma
Curriculum: Molecular Oncology
N. Gauthier (IFOM)
Diversity in Glioblatoma mechanoproperties
Curriculum: Molecular Oncology
N. Gauthier (IFOM)
Linking T-cell clonal expansions to TCR specificities in immune-mediated disease
Curriculum: computational biology
Regulatory and helper T-cell subsets in health and disease
Curriculum: Molecular Oncology
Development of a 3D assembloid model to study host-virus interactions in the human nervous system.
Curriculum: Molecular Oncology
O. Harschnitz (HT)
Targeting ADA-SCID neuropathology in a patient-derived organoid platform.
Curriculum: Molecular Oncology
O. Harschnitz (HT)
Exploiting epigenetic-aging mechanisms for the discovery of cancer therapeutic targets
Curriculum: computational biology
F. Iorio (HT)
Analytical methods for pharmacogenomics
Curriculum: computational Biology
F. Iorio (HT)
Brain plasticity in glioma
Curriculum: Molecular Oncology
N. Kalebic (HT)
molecular and cell biological mechanisms underlying human neocortical development
Curriculum: Molecular Oncology
N. Kalebic (HT)
Novel senolytic targets for the treatment of age-associated diseases
Curriculum: Molecular Oncology
M. Kovatcheva (IFOM)
Cell plasticity and aging
Curriculum: Molecular Oncology
M. Kovatcheva (IFOM)
Regulation of spatial gene expression territories in neurodevelopment.
Curriculum: Molecular Oncology
I. Legnini (HT)
The role of RNA binding proteins in neuronal transcriptome plasticity
Curriculum: Molecular Oncology
I. Legnini (HT)
Molecular principles of intestinal stem cell self-renewal
Curriculum: Molecular Oncology
M. Mapelli (IEO)
Molecular Basis of Asymmetric Cell Divisions
Curriculum: Molecular Oncology
M. Mapelli (IEO)
Molecular and functional analysis of pancreatic cancer heterogeneity
Curriculum: Molecular Oncology
G. Natoli (IEO)
Transcriptional Control in Inflammation and Cancer
Curriculum: Molecular Oncology
G. Natoli (IEO)
Charting the tumor ecosystem by spatially resolved methodologies
Curriculum: Molecular Oncology
Molecular Oncology and immunology
Curriculum: Molecular Oncology
Single-cell resolution and spatial reconstruction of bladder cancer heterogeneity
Curriculum: Molecular Oncology
Hormone-Related Cancers and Stem Cell Pathobiology
Curriculum: Molecular Oncology
Non-genetic mechanisms of drug-resistance in Acute Myeloid Leukemia (AML).
Curriculum: Molecular Oncology
Breast-cancer cell-phenotypes selected during metastatization and treatment.
Curriculum: Molecular Oncology
Functional and genetic characterization of Enhancer-promoter networks in breast cancer.
Curriculum: computational biology
Bioinformatics approaches for the analysis of the genome and epigenome from single molecule sequencing data
Curriculum: computational biology
G. Pesole (UNIBA)
Study of the microbiome in clinical and environmental samples using metagenomic approaches
Curriculum: computational Biology
G. Pesole (UNIBA)
Predicting antibiotic resistance evolution
Curriculum: computational biology
F. Pinheiro (HT)
Predicting ecological and evolutionary processes
Curriculum: computational Biology
F. Pinheiro (HT)
Elucidating the impact of alternative splicing in colorectal cancer via multi-omics data integration
Curriculum: computational biology
Unraveling the role of oncogenic deubiquitinating enzymes in colorectal cancer
Curriculum: Molecular Oncology
Molecular Machines in Signalling Pathways
Curriculum: Molecular Oncology
eHealth technologies to promote primary cancer prevention
Curriculum: medical humanities
Digital solutions to tackle mental health in cancer patients and their families
Curriculum: medical humanities
XAI - Bridging the Gap: Exploring Artificial Intelligence Explainability and Interpretability in Medical Humanities
Curriculum: medical humanities
Analysis of the role of the choroid plexus and the microbiota in brain tumor metastasis formation
Curriculum: Molecular Oncology
M. Rescigno (Humanitas University)
Mucosal immunology and microbiota
Curriculum: Molecular Oncology
M. Rescigno (Humanitas University)
Deciphering and exploiting aneuploidy in cancer
Curriculum: Molecular Oncology
Genome integrity
Curriculum: Molecular Oncology
CRISPR-based Saturation Gene Editing to dissect epigenetic mechanisms promoting cancer development
Curriculum: Molecular Oncology
P. Scaffidi (IEO)
Understanding and predicting the response to epigenetic drugs: from a robust regulatory network to acquired vulnerabilities
Curriculum: computational biology
P. Scaffidi (IEO)
Cancer Epigenetics
Curriculum: Molecular Oncology
P. Scaffidi (IEO)
The hidden drivers of cancer
Curriculum: computational biology
M. Schaefer (IEO)
Computational cancer biology
Curriculum: computational biology
M. Schaefer (IEO)
Identification of a mechano-based prognostic score in breast cancer
Curriculum: Molecular Oncology
Mechanisms of Tumor Cell Migration
Curriculum: Molecular Oncology
Microbiome signatures of early on-set colorectal cancer risk factors
Curriculum: computational biology
N. Segata (UNITN)
Metagenomics, microbiome, bacterial infection
Curriculum: computational biology
N. Segata (UNITN)
Role of endocytosis in cell plasticity, breast cancer progression and metastasis
Curriculum: Molecular Oncology
Dissecting gene-environment interactions in human brain development and neurodevelopmental disorders through brain organoid and single cell multi-omic modelling
Curriculum: Molecular Oncology
G. Testa
Stem Cell and Organoid Epigenetics
Curriculum: Molecular Oncology
G. Testa
Exploring the tumor ecosystem in the emerging scenario of cancer in beta-thalassemia
Curriculum: Molecular Oncology
C. Tripodo UNIPA
hystopathology and tumor microenviroment
Curriculum: Molecular Oncology
C. Tripodo UNIPA
Extra transcriptional roles of human RNA Polymerase III
Curriculum: Molecular Oncology
A. Vannini (HT)
Integrative structural biology of genome structure and organization
Curriculum: Molecular Oncology
A. Vannini (HT)
Membrane dynamics and tissue morphogenesis
Curriculum: Molecular Oncology
M. Zerial (HT)
Biochemical and biophysical approaches to study receptor endocytosis and endosomal membrane fusion
Curriculum: Molecular Oncology
M. Zerial (HT)
3D reconstruction and image analysis of liver tissue
Curriculum: computational biology
M. Zerial (HT)
Spatial Transcriptomics to Study the Autistic-Like Phenotype of CDKL5 Deficiency
Curriculum: human genetics
D. Cacchiarelli UNINA
A deep mutational scanning approach to dissect the molecular bases of rare genetic diseases
Curriculum: human genetics
D. Cacchiarelli UNINA
Cilia dysfunction and rare diseases
Curriculum: human genetics
B. Franco UNINA
Development of novel therapies for urea cycle disorders
Curriculum: human genetics
N. Brunetti Pierri UNINA
Dissecting mTOR-TFEB axis in mTORopathies
Curriculum: human genetics
A. Ballabio UNINA
To identify key factors essential for TFEB trascriptional regulation by CRISPr Screening
Curriculum: human genetics
A. Ballabio UNINA
Targeting copper-associated transporting pathways in Wilson disease and liver cancer
Curriculum: human genetics
R. Polishchuk UNINA

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