Technology-Driven Organic Synthesis
A.Y. 2024/2025
Learning objectives
The course aims at presenting innovative and alternative organic synthetic methods, with low environmental impact, economically sustainable, based on the use of new technologies. The learning objectives of the course are the following:
- to introduce the students to the use of enabling technologies in organic chemistry to carry out alternative/innovative syntheses of pharmaceutical products and, in general, of fine chemicals.
- to present the general concepts of flow chemistry (advantages, equipment) and its applications, both at laboratory and industrial level, for the creation of unprecedented synthetic processes;
- to introduce the use of photocatalysis in organic synthesis for the formation of C-C and C-X bonds promoted by light. The advantages of carrying out photocatalysed reactions in continuous flow conditions will be highlighted through examples reported in the literature;
- to introduce the use of electrochemistry in organic synthesis, applied to the preparation of functionalized small molecules, presenting both the equipment and the new synthetic methodologies;
- to introduce the general concepts of artificial intelligence and machine learning applied to organic synthesis
- to introduce the students to the use of enabling technologies in organic chemistry to carry out alternative/innovative syntheses of pharmaceutical products and, in general, of fine chemicals.
- to present the general concepts of flow chemistry (advantages, equipment) and its applications, both at laboratory and industrial level, for the creation of unprecedented synthetic processes;
- to introduce the use of photocatalysis in organic synthesis for the formation of C-C and C-X bonds promoted by light. The advantages of carrying out photocatalysed reactions in continuous flow conditions will be highlighted through examples reported in the literature;
- to introduce the use of electrochemistry in organic synthesis, applied to the preparation of functionalized small molecules, presenting both the equipment and the new synthetic methodologies;
- to introduce the general concepts of artificial intelligence and machine learning applied to organic synthesis
Expected learning outcomes
At the end of the course, the student is expected to:
- have acquired knowledge and understanding of the enabling technologies presented in the course and the advantages of their application in organic synthesis;
- have acquired competence and ability to discuss the enabling technologies applied to the synthesis of an organic compound;
- be able to propose a synthesis/transformation of a functionalized organic compound through the methods presented in the course;
- be able to independently carry out bibliographic research about the relevant scientific literature.
- have acquired knowledge and understanding of the enabling technologies presented in the course and the advantages of their application in organic synthesis;
- have acquired competence and ability to discuss the enabling technologies applied to the synthesis of an organic compound;
- be able to propose a synthesis/transformation of a functionalized organic compound through the methods presented in the course;
- be able to independently carry out bibliographic research about the relevant scientific literature.
Lesson period: First semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course can be attended as a single course.
Course syllabus and organization
Single session
Lesson period
First semester
Course syllabus
The teaching program includes the presentation and discussion of the following topics:
- flow chemistry: presentation of the advantages of continuous processes, also based on the 12 principles of Green Chemistry; presentation of the various types of reactors (tubular and CSTR) and possibility of developing home-made reactors also with the use of 3D printing. (2 CFU)
- photocatalysis: presentation of basic concepts; presentation of the equipment used; generation of radicals through the mediation of photocatalysts; applications to organic synthesis (1 CFU)
- examples of photocatalyzed reactions in continuous flow conditions (0,5 CFU)
- organic electrochemistry: presentation of basic concepts; presentation of the equipment used; generation of radicals; applications to organic synthesis (1 CFU)
- examples of electrochemical reactions in continuous flow conditions (0,5 CFU)
- artificial intelligence-machine learning: basic concepts and application to organic synthesis. (0,5 CFU)
- discussion of case studies. (0,5 CFU)
With the aim of allowing a better comprehension of the course contents and promoting the development of a critical discussion of a work of literature, moments of guided discussion will be offered to students during the teaching classes.
- flow chemistry: presentation of the advantages of continuous processes, also based on the 12 principles of Green Chemistry; presentation of the various types of reactors (tubular and CSTR) and possibility of developing home-made reactors also with the use of 3D printing. (2 CFU)
- photocatalysis: presentation of basic concepts; presentation of the equipment used; generation of radicals through the mediation of photocatalysts; applications to organic synthesis (1 CFU)
- examples of photocatalyzed reactions in continuous flow conditions (0,5 CFU)
- organic electrochemistry: presentation of basic concepts; presentation of the equipment used; generation of radicals; applications to organic synthesis (1 CFU)
- examples of electrochemical reactions in continuous flow conditions (0,5 CFU)
- artificial intelligence-machine learning: basic concepts and application to organic synthesis. (0,5 CFU)
- discussion of case studies. (0,5 CFU)
With the aim of allowing a better comprehension of the course contents and promoting the development of a critical discussion of a work of literature, moments of guided discussion will be offered to students during the teaching classes.
Prerequisites for admission
To adequately address the contents of the course, a good knowledge of organic chemistry is necessary, in particular the reactivity of functional groups and stereochemistry.
Teaching methods
Lectures, seminars held by experts. Attendance is strongly recommended.
Teaching Resources
Slides and literature papers will be available on MyAriel site.
Assessment methods and Criteria
The assessment method is an oral test with a mark out of thirty. The following criteria will be evaluated: the acquired knowledge; the ability to discursively organize knowledge; the ability to connect the different technologies covered; the quality of the presentation, also through the use of specialized vocabulary.
CHIM/06 - ORGANIC CHEMISTRY - University credits: 6
Lessons: 48 hours
Professors:
Benaglia Maurizio, Puglisi Alessandra
Professor(s)