Chemistry of Heterocyclic Compounds
A.Y. 2024/2025
Learning objectives
This course aims at providing the student with the knowledge on heterocyclic compounds, aromatic and non-aromatic, by examining their properties and reactivity and by illustrating important methods for their synthesis
Expected learning outcomes
Students will know aromatic and nonaromatic heterocycles; in particular, their structural, physical and spectroscopic features, important chemical properties, reactions and syntheses. They will know natural products, pharmaceuticals and other biologically active compounds of related structure type, and their use in synthesis and in selected synthetic transformations.
Lesson period: Second semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course can be attended as a single course.
Course syllabus and organization
Single session
Responsible
Lesson period
Second semester
Course syllabus
The description of each class of heterocyclic compounds will be organized in five issues:
1. Structure and properties
2. Reactivity
3. Synthetic strategies
4. Heterocyclic compounds in Nature, medicinal chemistry and materials science
5. Heterocyclic compounds in organic synthesis
The heterocycles will be considered are:
- Three membered rings: Oxirane, Thiirane, Aziridine
- Four membered rings: Oxetane, Thietane Azetidine
- Five membered rings: Furan, Benzofuran, Tetrahydrofuran, Thiophene, Benzothiophene, Pyrrole, Indole, Pyrrolidine, 1,2-Azoles, 1,3-Azoles
- Six membered rings: Pyridine, Peperidine, Quinoline, Isoquinoline
- Purines and Pyrimidines
- Seven membered rings: Azepine
1. Structure and properties
2. Reactivity
3. Synthetic strategies
4. Heterocyclic compounds in Nature, medicinal chemistry and materials science
5. Heterocyclic compounds in organic synthesis
The heterocycles will be considered are:
- Three membered rings: Oxirane, Thiirane, Aziridine
- Four membered rings: Oxetane, Thietane Azetidine
- Five membered rings: Furan, Benzofuran, Tetrahydrofuran, Thiophene, Benzothiophene, Pyrrole, Indole, Pyrrolidine, 1,2-Azoles, 1,3-Azoles
- Six membered rings: Pyridine, Peperidine, Quinoline, Isoquinoline
- Purines and Pyrimidines
- Seven membered rings: Azepine
Prerequisites for admission
Good knowledge of fundamental organic chemistry and the most important synthetic methods learned in organic chemistry I course
Teaching methods
traditional
Teaching Resources
- Class notes and slides
- book: "The Chemistry of Heterocycles", T. Eicher, S. Hauptmann, third edition
- book: "The Chemistry of Heterocycles", T. Eicher, S. Hauptmann, third edition
Assessment methods and Criteria
Written and oral: the written part will consist of a number of exercises (about 9-10) covering the course content: Nomenclature, Synthesis, Reactivity. The oral part will be a critical comment to the written part, followed by a discussion in order to ascertain the knowledge of the course content.
CHIM/06 - ORGANIC CHEMISTRY - University credits: 6
Lessons: 48 hours
Professor:
Giannini Clelia
Shifts:
Turno
Professor:
Giannini CleliaProfessor(s)