Toxicology I | Università degli Studi di Milano Statale

A.Y. 2024/2025

Max ECTS

Overall hours

SSD

BIO/14

Language

Italian

Included in the following degree programmes

Chemical Safety and Toxicological Environmental Sciences (Classe L-29)-Enrolled from 2009/10 Academic Year

Learning objectives

Aim of the course is to provide the fundamental knowledge to understand the basic principles of toxicology through:
- the characterization of toxicity manifestations and molecular mechanisms
- the scientific basis of experimental toxicology
- the analysis of the adverse effects of xenobiotics and drugs on organ
- the analysis of the criteria for evaluating and extrapolating toxicity data to humans

Expected learning outcomes

Students will acquire the ability to critically analyze and discuss, with a coherent language, the general pathways triggered by xenobiotics and drugs to alter organ physiology, the mechanisms involved and the general rules that define their toxicity.

Lesson period: First semester

Lessons timetable

Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi

Exams calendar

Single course

This course can be attended as a single course.

Take a single course

Course syllabus and organization

Single session

Responsible

Viviani Barbara

Lesson period

First semester

Syllabus
(active tab)
Course structure

Course syllabus

GENERAL PRINCIPLES OF TOXICOLOGY
· Principles of Toxicology: the concept of risk and dose, from molecular mechanism to the rules passing by risk assessment, type of toxicants, dose-response curves and relevance in toxicity, molecule-target relationship and related effects, reversible and irreversible, acute, subacute, subchronic and chronic toxicity, the different factors that influence toxicity
· Mechanisms of Toxicity: oxidative stress, mitochondrial toxicity, calcium homeostasis, molecular mechanism of protection and repair
· Toxicokinetics: absorption, distribution, metabolism and excretion of toxic substances
·
NON-ORGAN-DIRECTED TOXICITY
· Developmental toxicology: teratogenesis, developmental origins of health and disease (DOHaD)
· Genetic toxicology
· Carcinogenesis
TARGET ORGAN TOXICITY
· Toxic response of the reproductive system
·Toxic responses of the respiratory system
· Toxic responses of the immune system
· Toxic responses of the Nervous System
· Toxic responses of the kidney
· Toxic responses of the liver
· Toxic responses of the skin
RISK ASSESSMENT
·OECD Guidelines for the Testing of Chemicals
· In vitro methods and alternative approaches applied in toxicology
· Risk assessment

Prerequisites for admission

Knowledge of basic human anatomy and principles of biology

Teaching methods

The course is conducted through lectures and class discussion of the syllabus.

Teaching Resources

Tossicologia, Galli-Corsini-Marinovich, editore PICCIN, 2 Edizione (2008)
· Casarett e Doull's Tossicologia, i fondamenti dell'azione delle sostanze tossiche, Curtis D Klaassen, Ed. EMSI, 7 edizione
· Casarett e Doull's Toxicology. The basic science of poisons. Curtis D Klaassen, Ed. McGraw Hill, 7th Edition
Slides and supplementary material will be loaded on the web platform Ariel Unimi (https://ariel.unimi.it)

Assessment methods and Criteria

The aim of the course is to provide a basic knowledge of the principles of toxicology through the characterisation of the main mechanisms of toxicity at both cellular and organ levels. Acquisition of these competencies will be assessed independently by two different professors through an oral examination on any topic of the programme. The final mark, out of thirty, will be the average of the marks awarded by each professor.

BIO/14 - PHARMACOLOGY - University credits: 8

Lessons: 64 hours

Professor: Viviani Barbara

Educational website(s)

Tossicologia 1 (a.a. 2024/25)

Professor(s)

Viviani Barbara

Reception:

by appointment

Dip. di Scienze Farmacologiche, Via Balzaretti 9

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