Special Systems Pharmacology
A.Y. 2024/2025
Learning objectives
The major aim of the course will be to deepen the knowledge of chemotherapy and neuropsychopharmacology as well as the pharmacological aspects of the drugs most commonly used in either fields. The main classes of chemotherapic drugs (antibiotics, anticancer drugs) and drugs used for the treatment of psychiatric diseases (antidepressants, antipsychotics, anxiolytics, drugs for the treatment of bipolar disorder) will be investigated. Of both classes, some original scientific articles will be discussed with interactive critical discussion.
Expected learning outcomes
At the end of the course, the student must demonstrate to have learned the rationale for the therapeutic use of both macro-classes of drugs, deepening their mechanism of action and side effects, appropriately assessing their risk/benefit. Particular attention will be paid to the interactions and the possible manifestation of resistance to their use.
Lesson period: Second semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course can be attended as a single course.
Course syllabus and organization
Single session
Lesson period
Second semester
Prerequisites for admission
Not requested
Assessment methods and Criteria
Examination at once or divided into parts At once
Methods of assessing knowledge Oral examination
Vote Vote verbalized (from 1/30 to 30/30)
Methods of assessing knowledge Oral examination
Vote Vote verbalized (from 1/30 to 30/30)
Chemiotherapy
Course syllabus
1. Introduction to the course. General concept of microbiology and antibiotic therapy
2. Antibiotiocs: antimetabolites,sulfonamides, trimetoprim.
3. Antibiotics that inhibit the synthesis of bacterial wll: penicillin and chephalosporin
4. Antibiotics that inhibit protein synthesis: aminoglycosides, tetracyclines, chloramphenicol, macrolides.
5. Antibiotics that inhibit nucleic acid synthesis: rifampicin, fluoroquinolones
6. Antibiotic resistance
7. Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy
8. Antimalarials
9. Immunomodulators
10.Viruses and Antiviral therapy
11. Antiretroviral Agents and Treatment of HIV Infection
12. Treatment of Viral Hepatitis (HBV/HCV)
13. COVID and chemotherapy
13. General Principles in the Pharmacotherapy of Cancer
14. Antitumor drugs. Alkylating Anticancer drugs and platinum cordination complexes
15. Antibiotics .
16. Antimetabolites
17. Topoisomerase inhibitors
18: Hormonal therapy
17.Targeted therapyv(imatinib, gefitinib, bortezomib)
18. Chemoresistance to cancer therapy
19. New approaches: biothecnological drugs
20. Drug interaction in oncology
2. Antibiotiocs: antimetabolites,sulfonamides, trimetoprim.
3. Antibiotics that inhibit the synthesis of bacterial wll: penicillin and chephalosporin
4. Antibiotics that inhibit protein synthesis: aminoglycosides, tetracyclines, chloramphenicol, macrolides.
5. Antibiotics that inhibit nucleic acid synthesis: rifampicin, fluoroquinolones
6. Antibiotic resistance
7. Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy
8. Antimalarials
9. Immunomodulators
10.Viruses and Antiviral therapy
11. Antiretroviral Agents and Treatment of HIV Infection
12. Treatment of Viral Hepatitis (HBV/HCV)
13. COVID and chemotherapy
13. General Principles in the Pharmacotherapy of Cancer
14. Antitumor drugs. Alkylating Anticancer drugs and platinum cordination complexes
15. Antibiotics .
16. Antimetabolites
17. Topoisomerase inhibitors
18: Hormonal therapy
17.Targeted therapyv(imatinib, gefitinib, bortezomib)
18. Chemoresistance to cancer therapy
19. New approaches: biothecnological drugs
20. Drug interaction in oncology
Teaching Resources
· Basic and Clinical Pharmacology 14/e (LANGE Basic Science) 2018
Bertram Katzung
· Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e 2017
Laurence L. Brunton, Randa Hilal-Dandan, Björn C. Knollmann
Bertram Katzung
· Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e 2017
Laurence L. Brunton, Randa Hilal-Dandan, Björn C. Knollmann
Neuropsychopharmacology
Course syllabus
How to organize an experimental research in the field of neuropsychopharmacology: criteria and
principles. Acquisition of data from the scientific literature; structure and analysis of scientific works;
consultation of databases. Preparation of a scientific manuscript in the neuropsychopharmacological
field.
Validity of the use of in vitro methods for the study of neuropsychopharmacology: use of cell cultures
Validity of the use of in vivo methods for the study of neuropsychopharmacology: use of laboratory
animals (rodents). Use of laboratory animals: legislation and criteria. In vivo test for the determination of
pharmacological activity, related to selected classes of drugs. Biological variability; statistical elaboration
and analysis of the experimental results.
Study methods for psychiatric diseases: genetic models and environmental models. Biomarkers in
psychiatric research and their clinical implications. General considerations and applications.
Study methods of drugs with antidepressant activity
Study methods of drugs with antipsychotic activity
Methods of study of drugs with analgesic activity
Study methods of drugs with anxiolytic and hypnotic activity
Study of substance and non-substance addiction. Animal models for the study of drugs of abuse and
methods for the study of drugs that act on the mechanisms of gratification. Methods for identifying new
drugs of abuse and how to study them.
Study methods of drugs for neurodegenerative diseases.
Study methods of drugs of natural origin with application in the field of neuropsychopharmacology
Imaging techniques applied to neuropsychopharmacology.
principles. Acquisition of data from the scientific literature; structure and analysis of scientific works;
consultation of databases. Preparation of a scientific manuscript in the neuropsychopharmacological
field.
Validity of the use of in vitro methods for the study of neuropsychopharmacology: use of cell cultures
Validity of the use of in vivo methods for the study of neuropsychopharmacology: use of laboratory
animals (rodents). Use of laboratory animals: legislation and criteria. In vivo test for the determination of
pharmacological activity, related to selected classes of drugs. Biological variability; statistical elaboration
and analysis of the experimental results.
Study methods for psychiatric diseases: genetic models and environmental models. Biomarkers in
psychiatric research and their clinical implications. General considerations and applications.
Study methods of drugs with antidepressant activity
Study methods of drugs with antipsychotic activity
Methods of study of drugs with analgesic activity
Study methods of drugs with anxiolytic and hypnotic activity
Study of substance and non-substance addiction. Animal models for the study of drugs of abuse and
methods for the study of drugs that act on the mechanisms of gratification. Methods for identifying new
drugs of abuse and how to study them.
Study methods of drugs for neurodegenerative diseases.
Study methods of drugs of natural origin with application in the field of neuropsychopharmacology
Imaging techniques applied to neuropsychopharmacology.
Teaching Resources
- Basic and Clinical Pharmacology 14/e (LANGE Basic Science) 2018
Bertram Katzung
- Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e 2017
Laurence L. Brunton, Randa Hilal-Dandan, Björn C. Knollmann
Bertram Katzung
- Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e 2017
Laurence L. Brunton, Randa Hilal-Dandan, Björn C. Knollmann
Chemiotherapy
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 32 hours
Neuropsychopharmacology
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 32 hours