Principles of Quantitative Pharmaceutical Analysis and Laboratory for Quantitative Analysis
A.Y. 2024/2025
Learning objectives
Two didactic units composes the course: lectures (Principles of Quantitative Pharmaceutical Analysis) and individual laboratory training (Laboratory for Quantitative Analysis).
The objectives of the lectures consist in providing the knowledge needed to apply the analytical methods, already partially learned in the preparatory courses (General and Inorganic Chemistry, and Stoichiometry, Analytical Chemistry and Inorganic Analysis of Substances having Pharmaceutical Interest and Qualitative Analysis Laboratory), described in the current European Pharmacopoeia for the quantitative analysis of substances for pharmaceutical use.
Concerning the experimental practices, the students will acquire the skills needed for the dosage of pharmaceutical substances reported in the Italian and European Pharmacopoeias.
The objectives of the lectures consist in providing the knowledge needed to apply the analytical methods, already partially learned in the preparatory courses (General and Inorganic Chemistry, and Stoichiometry, Analytical Chemistry and Inorganic Analysis of Substances having Pharmaceutical Interest and Qualitative Analysis Laboratory), described in the current European Pharmacopoeia for the quantitative analysis of substances for pharmaceutical use.
Concerning the experimental practices, the students will acquire the skills needed for the dosage of pharmaceutical substances reported in the Italian and European Pharmacopoeias.
Expected learning outcomes
By the lectures, the students will have improved further their knowledge concerning the theoretical and practical aspects related to the quantitative analysis, which they will have applied during the individual experimental practices.
The laboratory experiences (mandatory) will have provided to the students the skills to perform the quantitative analysis of pharmaceutical compounds, to complete their knowledge (by means also of other courses as Assays and Methods of Analysis of the Pharmacopoeias and Laboratory of Drug Identification).
The laboratory experiences (mandatory) will have provided to the students the skills to perform the quantitative analysis of pharmaceutical compounds, to complete their knowledge (by means also of other courses as Assays and Methods of Analysis of the Pharmacopoeias and Laboratory of Drug Identification).
Lesson period: Second semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course can be attended as a single course.
Course syllabus and organization
Linea AL
Responsible
Lesson period
Second semester
Course syllabus
Programme of the lectures:
Introduction to the principles of medicinal chemical- quantitative analysis.
The current European Pharmacopea as a reference text for quantitative analyses of active ingredients, excipients, plant extracts and nutrients.
Statistical processing and evaluation of analytical data.
Development and validation of an analytical method.
Gravimetric analysis.
Volumetric analysis: definition of direct titrations, back- and indirect-titrations; acid-base titrations; precipitation-forming titration, oxidation-reduction titrations; complex-formation titrations; potentiometric titrations - non-aqueous titrations.
Analytical techniques described in the current European Pharmacopea applied to quantitative analysis.
Introduction to analytical techniques; potentiometry; elements of voltammetry and amperometry; optical methods: UV-Visible spectroscopy, fluorescence and phosphorescence; chromatography techniques: high-performance liquid chromatography, gas-chromatography and headspace analysis.
Programme of the laboratory exercises:
- Description of the analytical laboratory hardware (e.g. glassware, instruments, etc.);
- Complexation titrations
- Oxidation-reduction titration (permanganometry, iodimetry, Iodometry etc.)
- Acid- base titrations
- Precipitation titrations.
Introduction to the principles of medicinal chemical- quantitative analysis.
The current European Pharmacopea as a reference text for quantitative analyses of active ingredients, excipients, plant extracts and nutrients.
Statistical processing and evaluation of analytical data.
Development and validation of an analytical method.
Gravimetric analysis.
Volumetric analysis: definition of direct titrations, back- and indirect-titrations; acid-base titrations; precipitation-forming titration, oxidation-reduction titrations; complex-formation titrations; potentiometric titrations - non-aqueous titrations.
Analytical techniques described in the current European Pharmacopea applied to quantitative analysis.
Introduction to analytical techniques; potentiometry; elements of voltammetry and amperometry; optical methods: UV-Visible spectroscopy, fluorescence and phosphorescence; chromatography techniques: high-performance liquid chromatography, gas-chromatography and headspace analysis.
Programme of the laboratory exercises:
- Description of the analytical laboratory hardware (e.g. glassware, instruments, etc.);
- Complexation titrations
- Oxidation-reduction titration (permanganometry, iodimetry, Iodometry etc.)
- Acid- base titrations
- Precipitation titrations.
Prerequisites for admission
The course takes place in the second semester of the second year. The students are expected to have Analytical Chemistry, Analysis of inorganic substances for pharmaceutical use and Laboratory of qualitative analysis and Organic Chemistry knowledges.
Teaching methods
The course is structured in lectures and laboratory exercises (mandatory).
All information about the program and educational materials (slide) are available on the course website on myAriel platform.
All information about the program and educational materials (slide) are available on the course website on myAriel platform.
Teaching Resources
Recommended books:
Chimica analitica quantitativa - D. C. Harris - Zanichelli
Chimica analitica - Skoog, West, Holler - EdiSES
Chimica analitica e analisi quantitativa - D. S. Hage, J. D. Carr - Piccin
Principi di Analisi Farmaceutica - Cavrini V. Andrisano V. - Esculapio 2017
Analisi strumentale - Bauer, Christian, O'Reilly - Piccin
Analisi di preparazioni farmaceutiche -Giulio Cesare Porretta - CISU
Vogel's Textbook of quantitative Chemical analysis - Longman Eds
European Pharmacopoeia Online - EDQM website
Chimica analitica quantitativa - D. C. Harris - Zanichelli
Chimica analitica - Skoog, West, Holler - EdiSES
Chimica analitica e analisi quantitativa - D. S. Hage, J. D. Carr - Piccin
Principi di Analisi Farmaceutica - Cavrini V. Andrisano V. - Esculapio 2017
Analisi strumentale - Bauer, Christian, O'Reilly - Piccin
Analisi di preparazioni farmaceutiche -Giulio Cesare Porretta - CISU
Vogel's Textbook of quantitative Chemical analysis - Longman Eds
European Pharmacopoeia Online - EDQM website
Assessment methods and Criteria
The examination consists of a written test (120 minutes duration) based on problems related to the stechiometry and the chemical equilibrium of the various titration reactions, by critical evaluation of the analytical data, and questions concerning the theory of quantitative analysis and the application of the various analytical methods. The overall assessment is scored in thirtieth and it corresponds to the sum of the scores obtained in the written test (maximum score 24/30) and in the laboratory exercises (maximun score 6/30). The final score of the examination is communicated during the return and correction of the test. In the course of the lectures, ongoing exercises are proposed in preparation for the examination.
Laboratory for quantitative analysis
CHIM/08 - PHARMACEUTICAL CHEMISTRY - University credits: 2
Single bench laboratory practical: 32 hours
Professor:
Straniero Valentina
Shifts:
Turno 1
Professor:
Straniero Valentina
Principles of quantitative pharmaceutical analysis
CHIM/08 - PHARMACEUTICAL CHEMISTRY - University credits: 6
Lessons: 48 hours
Professor:
Gelain Arianna
Linea MZ
Responsible
Lesson period
Second semester
Course syllabus
Principles of Quantitative Pharmaceutical Analysis (Lessons)
Introduction to the principles of medicinal chemical- quantitative analysis.
The current European pharmacopea as a reference text for quantitative analyses of active ingredients, excipients, plant extracts and nutrients.
Statistical processing and evaluation of analytical data.
Development and validation of an analytical method.
Gravimetric analysis.
Volumetric analysis: Definition of direct titrations, back- and indirect-titrations; acid-base titrations; precipitation-forming titration, oxidation-reduction titrations; complex-formation titrations; potentiometric titrations - nonaqueous titrations.
Analytical techniques described in the current European Pharmacopea applied to quantitative analysis.
Introduction to analytical techniques; optical methods; UV-Visible spectroscopy, fluorescence and phosphorescence; chromatography techniques; high-performance liquid chromatography; gas-chromatography and Headspace analysis.
Program of the practical laboratory experiences:
- Illustration of the analytical laboratory hardware (e.g. glassware, instruments, etc.);
- complexation titrations;
- oxidation-reduction titration (permanganometry, iodimetry, Iodometry .
- acid- base titrations;
- precipitation titrations.
Introduction to the principles of medicinal chemical- quantitative analysis.
The current European pharmacopea as a reference text for quantitative analyses of active ingredients, excipients, plant extracts and nutrients.
Statistical processing and evaluation of analytical data.
Development and validation of an analytical method.
Gravimetric analysis.
Volumetric analysis: Definition of direct titrations, back- and indirect-titrations; acid-base titrations; precipitation-forming titration, oxidation-reduction titrations; complex-formation titrations; potentiometric titrations - nonaqueous titrations.
Analytical techniques described in the current European Pharmacopea applied to quantitative analysis.
Introduction to analytical techniques; optical methods; UV-Visible spectroscopy, fluorescence and phosphorescence; chromatography techniques; high-performance liquid chromatography; gas-chromatography and Headspace analysis.
Program of the practical laboratory experiences:
- Illustration of the analytical laboratory hardware (e.g. glassware, instruments, etc.);
- complexation titrations;
- oxidation-reduction titration (permanganometry, iodimetry, Iodometry .
- acid- base titrations;
- precipitation titrations.
Prerequisites for admission
The student must have a good knowledge of General and Analytical Chemistry and, in particular, of the chemical solution equilibriums.
Teaching methods
Lectures and laboratory experiences (mandatory).
All the info about the program and books/slides are available on myAriel platform.
All the info about the program and books/slides are available on myAriel platform.
Teaching Resources
All info about the program, books/slides are available on myARIEL website.
Recommended Books:
Chimica analitica quantitativa - D. C. Harris - Zanichelli
Chimica analitica - Skoog, West, Holler - EdiSES
Chimica analitica e analisi quantitativa - D. S. Hage, J. D. Carr - Piccin
Principi di Analisi Farmaceutica - Cavrini V. Andrisano V. - Esculapio 2017
Analisi strumentale - Bauer, Christian, O'Reilly - Piccin
Analisi di preparazioni farmaceutiche -Giulio Cesare Porretta - CISU
Vogel's Textbook of quantitative Chemical analysis - Longman Eds
European Pharmacopoeia Online - EDQM website
Recommended Books:
Chimica analitica quantitativa - D. C. Harris - Zanichelli
Chimica analitica - Skoog, West, Holler - EdiSES
Chimica analitica e analisi quantitativa - D. S. Hage, J. D. Carr - Piccin
Principi di Analisi Farmaceutica - Cavrini V. Andrisano V. - Esculapio 2017
Analisi strumentale - Bauer, Christian, O'Reilly - Piccin
Analisi di preparazioni farmaceutiche -Giulio Cesare Porretta - CISU
Vogel's Textbook of quantitative Chemical analysis - Longman Eds
European Pharmacopoeia Online - EDQM website
Assessment methods and Criteria
The verification of the learning is carried out by a written test (90 minutes).
The examination consists of a written test based on the resolution of problems related to the stechiometry and the chemical equilibrium of the various titration's reactions and open-ended questions concerning the theory of quantitative analysis covered during the course. The marks obtained is scored in thirtieth and results from the sum of the scores obtained in the written test (maximum score 24/30) and in the laboratory exercises (maximun score 6/30). During the course ongoing exercises are proposed in preparation for the exam.
The examination consists of a written test based on the resolution of problems related to the stechiometry and the chemical equilibrium of the various titration's reactions and open-ended questions concerning the theory of quantitative analysis covered during the course. The marks obtained is scored in thirtieth and results from the sum of the scores obtained in the written test (maximum score 24/30) and in the laboratory exercises (maximun score 6/30). During the course ongoing exercises are proposed in preparation for the exam.
Laboratory for quantitative analysis
CHIM/08 - PHARMACEUTICAL CHEMISTRY - University credits: 2
Single bench laboratory practical: 32 hours
Professor:
Fumagalli Laura
Shifts:
Turno 2
Professor:
Fumagalli Laura
Principles of quantitative pharmaceutical analysis
CHIM/08 - PHARMACEUTICAL CHEMISTRY - University credits: 6
Lessons: 48 hours
Professor:
Fumagalli Laura
Professor(s)