Pathogenetic basis of diseases
A.Y. 2024/2025
Learning objectives
The course aims to develop knowledge on the pathogenic basis of human diseases, with particular attention to limits and benefits of the main experimental models available and their correlation with clinical presentation of the disease. It is based on a series of lectures grouped on thematic sections and focusing on pathogenic mechanisms and experimental approaches. The course also includes two journal club sessions held by the students on selected scientific articles proposed by the Faculty, aimed at developing the student's ability to critical reading, presentation, and discussion of the scientific data.
Expected learning outcomes
Students will acquire an integrated comprehension of the pathogenic basis of human pathology and on the correlation of pathogenic mechanisms and clinical manifestations. They will also acquire information on potentials and limitations of experimental models available. The journal club sessions will allow them to develop critical reading, presentation, and scientific data discussion abilities.
Lesson period: First trimester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course can be attended as a single course.
Course syllabus and organization
Single session
Responsible
Lesson period
First trimester
Prerequisites for admission
There is no specific preliminary knowledge
Assessment methods and Criteria
The exam is based on a written test, composed of 32 multiple-choice questions, covering the modules that compose the program (immunology, oncology, internal medicine). The test will be performed in informatic rooms of the University, through the Moodle platform. Each exact answer will value one point, no penalty for wrong answers, the test will result in a mark from 18 to 30L. The students can choose to stay until the end of the test to visualize the results together with the teacher. Registration through SIFA is mandatory.
General pathology and immunology
Course syllabus
General pathology, immunology and oncology
Transplantation immunology.
The graft versus host disease: experimental models and implications for bone marrow transplant.
Pathogenic mechanisms in primary and acquired immunodeficiencies.
The immune contexture of solid tumors. Role of adaptive immunity in cancer.
Pathogenic mechanisms in allergic diseases.
Pathogenic mechanisms in autoimmune diseases.
The immune contexture of solid tumors. Biomarker discovery.
Immunotherapy with checkpoint inhibitors: predictive biomarkers.
Immunothrombosis: an evolutionary response.
Ovary carcinoma: clinical presentation and experimental models.
Molecular phenotypes of mammary carcinoma: clinical presentations and experimental models.
Pathogen recognition and septic shock.
Immune escape mechanisms by pathogens.
The inflammasome and auto-inflammatory syndromes.
Inflammation resolution: molecular mechanisms and experimental models.
Diffuse glioma: clinical presentation and experimental models.
Cancer metastasis: mechanisms and experimental models.
Transplantation immunology.
The graft versus host disease: experimental models and implications for bone marrow transplant.
Pathogenic mechanisms in primary and acquired immunodeficiencies.
The immune contexture of solid tumors. Role of adaptive immunity in cancer.
Pathogenic mechanisms in allergic diseases.
Pathogenic mechanisms in autoimmune diseases.
The immune contexture of solid tumors. Biomarker discovery.
Immunotherapy with checkpoint inhibitors: predictive biomarkers.
Immunothrombosis: an evolutionary response.
Ovary carcinoma: clinical presentation and experimental models.
Molecular phenotypes of mammary carcinoma: clinical presentations and experimental models.
Pathogen recognition and septic shock.
Immune escape mechanisms by pathogens.
The inflammasome and auto-inflammatory syndromes.
Inflammation resolution: molecular mechanisms and experimental models.
Diffuse glioma: clinical presentation and experimental models.
Cancer metastasis: mechanisms and experimental models.
Teaching methods
Frontal lessons based on teaching material available on the Ariel platform or provided directly in the classroom to students.
Attendance is compulsory
Attendance is compulsory
Teaching Resources
Slides produced during the course. Scientific literature suggested by the teachers.
Internal medicine
Course syllabus
Iron metabolism and erythropoiesis
Anemias
Iron overload disorders
Iron metabolism and hereditary hemochromatosis.
Metabolic diseases
The metabolic syndrome and type 2 diabetes
Experimental models of insulin resistance and nonalcoholic fatty liver disease
Pathophysiology and genetics of a complex disease: nonalcoholic steatohepatitis.
Liver and kidney diseases
Liver diseases (viral, cholestatic and autoimmune) and hepatocellular carcinoma
Human genetics and models of metabolic diseases
Kidney diseases
Seminars: applications of stem cells for in vitro modelling and treatment of human disorders, applications of cytofluorimetry and cell sorting for the study of human diseases.
Diseases of the cardiovascular system
Thrombosis, thrombogenesis and thrombotic diseases
Atherosclerosis and arterial thrombosis: coronary heart disease and ischemic cerebrovascular disease
Venous thromboembolism
Heart remodeling in systemic hypertension, heart failure, coronary heart disease, and atrial fibrillation
Modeling biologic systems: network based simulation for translational medicine: an application to anticoagulation
Antithrombotic pharmacological and non-pharmacological therapy.
Aging and age-related diseases
Aging
Immune senescence and inflammaging
Premature lung aging in the pathogenesis of respiratory diseases
Cerebral aging and neurodegenerative diseases
Alzheimer: pathogenesis and biomarkers.
Journal Club Sessions
Anemias
Iron overload disorders
Iron metabolism and hereditary hemochromatosis.
Metabolic diseases
The metabolic syndrome and type 2 diabetes
Experimental models of insulin resistance and nonalcoholic fatty liver disease
Pathophysiology and genetics of a complex disease: nonalcoholic steatohepatitis.
Liver and kidney diseases
Liver diseases (viral, cholestatic and autoimmune) and hepatocellular carcinoma
Human genetics and models of metabolic diseases
Kidney diseases
Seminars: applications of stem cells for in vitro modelling and treatment of human disorders, applications of cytofluorimetry and cell sorting for the study of human diseases.
Diseases of the cardiovascular system
Thrombosis, thrombogenesis and thrombotic diseases
Atherosclerosis and arterial thrombosis: coronary heart disease and ischemic cerebrovascular disease
Venous thromboembolism
Heart remodeling in systemic hypertension, heart failure, coronary heart disease, and atrial fibrillation
Modeling biologic systems: network based simulation for translational medicine: an application to anticoagulation
Antithrombotic pharmacological and non-pharmacological therapy.
Aging and age-related diseases
Aging
Immune senescence and inflammaging
Premature lung aging in the pathogenesis of respiratory diseases
Cerebral aging and neurodegenerative diseases
Alzheimer: pathogenesis and biomarkers.
Journal Club Sessions
Teaching methods
Frontal lessons based on teaching material available on the Ariel platform or provided directly in the classroom to students.
Class attendance is free.
Class attendance is free.
Teaching Resources
Slides produced during the course. Scientific literature suggested by the teachers.
General pathology and immunology
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 6
Lessons: 42 hours
Shifts:
Internal medicine
MED/09 - INTERNAL MEDICINE - University credits: 6
Lessons: 42 hours
Professors:
Tobaldini Eleonora, Valenti Luca Vittorio Carlo
Shifts:
Educational website(s)
Professor(s)
Reception:
by appointment (e-mail request)
Marangoni pavilion, Policlinico IRCCS hospital, via F Sforza 35, Milan