Organometallic Chemistry and Fine Chemical Applications

- Classification of ligands as defined by the Hard and Soft Acid Base theory (HSAB). Crystal field theory. Trans effect in coordination chemistry. Backbonding and electroneutrality principle. The 18-electron rule and its limitations. Ligand-field d-orbital splitting in transition metal complexes' formation. Different types of coordination geometries. Chirality in coordination complexes. Different ligands and the importance of their properties in coordination chemistry. Oxidative-addition and reductive-elimination: study of mechanism. Migratory insertion and isomerization reactions of olefins
- Ruthenium, Rhodium and Iridium: reactivity and their application in asymmetric catalysis. Copper, Silver and Gold: reactivity and their application in asymmetric catalysis. Peptides as innovative ligands in transition metal complexes.- An insight into the reactivity of metal-based enzymes. Hybrid catalysts and artificial metalloenzymes.

Homogeneous and heterogeneous catalysis. Formation of C-C, C-N, C-O bonds by using transition metals complexes. Reactions catalyzed by Pd(0)-complexes: Heck, Buchwald-Hartwig, cross-coupling, stereoselective reactions. Reactions catalyzed by Pd(II)-complexes: C-H activation, formation of C-C, C-N, C-O bonds. Domino reactions. Metathesis reactions catalyzed by Rutenium. Catalysis of different transition metals (Pt, Au, Cu, Rh, Ru). Comparison of different transition metals, stability, costs and user-friendliness. Choice of different catalysts applied to the syntheis of alkaloids and pharmaceuticals.