Medical Sciences
A.Y. 2024/2025
Learning objectives
The learning objectives of the Medical Sciences course are:
- to know the genetic and biological mechanisms;
- to know the main pathological mechanisms;
- to know the main anatomical and histological alterations;
- to know the principles of pharmacology.
- to know the genetic and biological mechanisms;
- to know the main pathological mechanisms;
- to know the main anatomical and histological alterations;
- to know the principles of pharmacology.
Expected learning outcomes
At the end of the course the student will have to know the genetic and biological mechanisms and their alterations, to know the etiopathogenetic factors underlying the structural and functional alterations involved in human pathology, and to know the principles of pharmacology.
Lesson period: Second semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course can be attended as a single course.
Course syllabus and organization
Single session
Prerequisites for admission
There are no specific prerequisites different from those required for admission to the degree course
Assessment methods and Criteria
The final exam will take place through a written test with multiple choice questions. The duration of the scheduled test is 1 hour maximum for each module.
The evaluation criteria will be the ability to understand the topics addressed during class lessons.
The final mark will be obtained by the average of the marks acquired in each course module and will be expressed by using 30/30 scale. No intermediate tests are foreseen. The results of the exam will be communicated to the students online by the secretary of the degree course.
The evaluation criteria will be the ability to understand the topics addressed during class lessons.
The final mark will be obtained by the average of the marks acquired in each course module and will be expressed by using 30/30 scale. No intermediate tests are foreseen. The results of the exam will be communicated to the students online by the secretary of the degree course.
Pharmacology
Course syllabus
1. Drug interactions
2. Effect of agonist and antagonist drugs
3. Pharmacokinetics absorption and distribution of drugs
4. Pharmacokinetics metabolism and elimination of drugs
5. Pharmacovigilance
6. Pharmacogenetics
2. Effect of agonist and antagonist drugs
3. Pharmacokinetics absorption and distribution of drugs
4. Pharmacokinetics metabolism and elimination of drugs
5. Pharmacovigilance
6. Pharmacogenetics
Teaching methods
Lectures
Teaching Resources
AA VV Farmacologia generale e molecolare a cura di F. Clementi e G Fumagalli, editore Edra SpA
Medical genetics
Course syllabus
Cell division: mitosis and meiosis.
Human genome: chromosome structure, karyotype and cytogenetic analyses. Chromosomal abnormalities in number and structure. DNA mutations and their classification.
Human DNA sequencing.Mendelianlaws and patterns of inheritance: autosomal dominant, autosomal recessive, and sex- linked ones.
Chromosome X inactivation.
Family trees and confounding factors: variable expressivity, incomplete penetrance, genetic heterogeneity, de novo mutations.
Atypical mechanisms of inheritance and complex diseases.
Genetics of deafness and speech disorders.
Human genome: chromosome structure, karyotype and cytogenetic analyses. Chromosomal abnormalities in number and structure. DNA mutations and their classification.
Human DNA sequencing.Mendelianlaws and patterns of inheritance: autosomal dominant, autosomal recessive, and sex- linked ones.
Chromosome X inactivation.
Family trees and confounding factors: variable expressivity, incomplete penetrance, genetic heterogeneity, de novo mutations.
Atypical mechanisms of inheritance and complex diseases.
Genetics of deafness and speech disorders.
Teaching methods
Lectures
Teaching Resources
Korf -Irons - Genetica e Genomica Umane - Edi-Ermes
- Neri-Genuardi - Genetica Umana e Medica - Ed Edra
- Thompson &Thompson - Genetica in Medicina - Ed Edises
- Neri-Genuardi - Genetica Umana e Medica - Ed Edra
- Thompson &Thompson - Genetica in Medicina - Ed Edises
Experimental medicine and pathophysiology
Course syllabus
· Homeostasis. Health and disease. Etiology and pathogenesis.
· Basic Immunology: innate and acquired immunity. Functions and disorders of the immune system.
· Cell injury: biochemical and molecular mechanisms. Causes of cell injury: hypoxia and ischemia, free radicals.
· Cell death: necrosis and apoptosis.
· Inflammation and repair. Overview of inflammation. Acute inflammation: reaction of blood vessels, recruitment of leukocytes and phagocytosis. Mediators of inflammation: histamine, nitric oxide, PAF, arachidonic acid derivatives, complement system, cytokines and chemokines. Chronic inflammation: morphologic patterns, mediators, granulomas. Tissue regeneration and repair: healing of skin wounds and fibrosis.
· Atherosclerosis and its complications. Stroke and TIA among the causes of aphasias.
· Cell adaptation: hypertrophy, hyperplasia, hypertrophy, athrophy, metaplasia.
· Neoplasia. Characterization of benign and malignant neoplasms. Cellular and molecular hallmark of cancer. Cancerogenesis: chemical, radiation and microbial carcinogens. Metastasis. Angiogenesis. Clinical aspects of neoplasia. Laryngeal carcinoma.
· Basic Immunology: innate and acquired immunity. Functions and disorders of the immune system.
· Cell injury: biochemical and molecular mechanisms. Causes of cell injury: hypoxia and ischemia, free radicals.
· Cell death: necrosis and apoptosis.
· Inflammation and repair. Overview of inflammation. Acute inflammation: reaction of blood vessels, recruitment of leukocytes and phagocytosis. Mediators of inflammation: histamine, nitric oxide, PAF, arachidonic acid derivatives, complement system, cytokines and chemokines. Chronic inflammation: morphologic patterns, mediators, granulomas. Tissue regeneration and repair: healing of skin wounds and fibrosis.
· Atherosclerosis and its complications. Stroke and TIA among the causes of aphasias.
· Cell adaptation: hypertrophy, hyperplasia, hypertrophy, athrophy, metaplasia.
· Neoplasia. Characterization of benign and malignant neoplasms. Cellular and molecular hallmark of cancer. Cancerogenesis: chemical, radiation and microbial carcinogens. Metastasis. Angiogenesis. Clinical aspects of neoplasia. Laryngeal carcinoma.
Teaching methods
Lectures
Teaching Resources
J. Maier. PATOLOGIA GENERALE E FISIOPATOLOGIA. Mc GrawHillJ.
Pathology
Course syllabus
· Concepts of hyperplasia, hypertrophy, cellular atypia, dysplasia, neoplasia.
· concept and meaning of carcinoma in situ and invasive carcinoma
· grading and staging of malignancies (TNM)
· pathology of the larynx (congenital malformations; polyps and laryngeal nodules, laryngitis; squamous cell carcinoma)
· oral pathology: a) malformative (micrognathia; labiopalatoschisis; macroglossia) b) non-neoplastic pathology (ulcerated lesions of the oral cavity; leukoplakia; candidiasis; herpetic lesions) c) oral pathology in the course of AIDS: warty leukoplakia and Kaposi's sarcoma. d) squamous cell carcinoma of the oral cavity, e) precancerous lesions and conditions, f) rare tumors oF the oral cavity: lymphomas, melanoma and rhabdomyosarcoma, g) odontogenic cysts and odontogenic tumors
· pathology of the salivary glands: outline of the anatomy and histology of the major and minor salivary glands; mumps; s.diSjogren; tumors (pleomorphic adenoma, T. warthin, adenoid cystic carcinoma, mucoepidermoid carcinoma)
· pathology of the pharynx and upper respiratory tract. Background.
· neck cyst (thyroglossal duct cyst)
· ear pathology: osteoma and cholesteatoma
· ear pathology
· concept and meaning of carcinoma in situ and invasive carcinoma
· grading and staging of malignancies (TNM)
· pathology of the larynx (congenital malformations; polyps and laryngeal nodules, laryngitis; squamous cell carcinoma)
· oral pathology: a) malformative (micrognathia; labiopalatoschisis; macroglossia) b) non-neoplastic pathology (ulcerated lesions of the oral cavity; leukoplakia; candidiasis; herpetic lesions) c) oral pathology in the course of AIDS: warty leukoplakia and Kaposi's sarcoma. d) squamous cell carcinoma of the oral cavity, e) precancerous lesions and conditions, f) rare tumors oF the oral cavity: lymphomas, melanoma and rhabdomyosarcoma, g) odontogenic cysts and odontogenic tumors
· pathology of the salivary glands: outline of the anatomy and histology of the major and minor salivary glands; mumps; s.diSjogren; tumors (pleomorphic adenoma, T. warthin, adenoid cystic carcinoma, mucoepidermoid carcinoma)
· pathology of the pharynx and upper respiratory tract. Background.
· neck cyst (thyroglossal duct cyst)
· ear pathology: osteoma and cholesteatoma
· ear pathology
Teaching methods
Lectures
Teaching Resources
Robbins - Cotran - Kumar - Klatt - AAVV- ANATOMIA PATOLOGICA
Experimental medicine and pathophysiology
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 1
Lessons: 10 hours
Professor:
Castiglioni Sara
Shifts:
Turno
Professor:
Castiglioni Sara
Medical genetics
MED/03 - MEDICAL GENETICS - University credits: 1
Lessons: 10 hours
Professor:
Ratti Antonia
Shifts:
Turno
Professor:
Ratti Antonia
Pathology
MED/08 - PATHOLOGY - University credits: 1
Lessons: 10 hours
Professor:
Nebuloni Manuela
Shifts:
Turno
Professor:
Nebuloni Manuela
Pharmacology
BIO/14 - PHARMACOLOGY - University credits: 1
Lessons: 10 hours
Professor:
Clementi Emilio Giuseppe Ignazio
Shifts:
Turno
Professor:
Clementi Emilio Giuseppe IgnazioProfessor(s)
Reception:
on appointment to be organised via e-mail
"Palazzina LITA-Vialba"