Design and Optimization of Monoclonal Antibodies
A.Y. 2024/2025
Learning objectives
The purpose of this course is that participants gain knowledge on and understand:
- the principal biological features of mAbs used both in research and therapy
- the computational strategies, and their accuracy, for studying and modelling mAbs
- the main methods to produce mAbs, and to in silico and in vitro predict and validate their mechanisms of action (MoA)
- the safety and efficacy of monoclonal antibodies in vivo, with key examples of their application in the clinical setting
- the principal biological features of mAbs used both in research and therapy
- the computational strategies, and their accuracy, for studying and modelling mAbs
- the main methods to produce mAbs, and to in silico and in vitro predict and validate their mechanisms of action (MoA)
- the safety and efficacy of monoclonal antibodies in vivo, with key examples of their application in the clinical setting
Expected learning outcomes
At the end of the course, the student is expected:
- to know:
- the principal biological features of mAbs
- the application of the molecular and computational methods used in mAb analyses and design
-the different mechanisms of action of mAbs
- to critically evaluate:
- the pros and cons of in silico and in vitro approaches for mAb design and production
- the efficacy and safety of mAbs in clinical trials
to gain:
- the bases for deeply understanding development methods and applications of mAbs in research and therapy, with particular attention to scientific papers and/or clinical data and reports;
to obtain:
a multifaceted biological, bioinformatics and pharmacological knowledgebase useful for further student's personal study of this topic.
- to know:
- the principal biological features of mAbs
- the application of the molecular and computational methods used in mAb analyses and design
-the different mechanisms of action of mAbs
- to critically evaluate:
- the pros and cons of in silico and in vitro approaches for mAb design and production
- the efficacy and safety of mAbs in clinical trials
to gain:
- the bases for deeply understanding development methods and applications of mAbs in research and therapy, with particular attention to scientific papers and/or clinical data and reports;
to obtain:
a multifaceted biological, bioinformatics and pharmacological knowledgebase useful for further student's personal study of this topic.
Lesson period: Second semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course can be attended as a single course.
Course syllabus and organization
Educational website(s)
Professor(s)
Reception:
On Mondays, Wednesdays and Fridays from 9 to 10 am and on appointment previously taken via Microsoft Teams or email
Microsoft Teams
Reception:
on appointment