Communicable and Non-Communicable Diseases

A.Y. 2024/2025
8
Max ECTS
64
Overall hours
SSD
BIO/19 MED/04
Language
English
Learning objectives
The objective of the course is to provide a specific knowledge and a critical evaluation on the pathological bases for precision medicine interventions. The overall learning objective is thus to provide an updated discussion of selected topics on precision medicine, which is notoriously a present and future important biomedical approach and includes relevant biotechnological aspects. The course includes two modules: Pathological bases for precision medicine interventions and Infectious diseases and drug resistance. In the first module, the following topics will be discussed: general principles of precision medicine, molecular determinants of individual health, precision medicine in oncology (molecular determinants, examples of precision medicine in oncology), precision medicine in cardiovascular and metabolic health, machine learning and artificial intelligence for precision medicine. In the second module, the following topics will be discussed: overview of human-microbe interactions, antimicrobial compounds: mechanism of action and resistance, identifying novel conventional targets for antimicrobial discovery, and non-conventional targets for novel generation of antimicrobial compounds, challenges in novel antimicrobial compound discovery.
Expected learning outcomes
At the end of the course, the students are expected to possess a solid knowledge and understanding on the pathological bases for precision medicine interventions. The acquired skills and competencies will be the tools through which the students will improve their capacity to correlate the different concepts in different areas of precision medicine, applying their skills to the comprehension of complex problems in this field. Moreover, they will be enabled to implement better judgment, communication skills and learning abilities in this complex scientific area, especially in relationship with topics relevant to biotechnology.
Single course

This course can be attended as a single course.

Course syllabus and organization

Single session

Responsible
Lesson period
First semester
Course syllabus
The course includes two modules: Pathological bases for precision medicine interventions and Infectious diseases and drug resistance.
In the first module, the following topics will be discussed:
a) Cardiovascular diseases
b) hypertension
c) metabolic syndrome and obesity
d) diabetes
e) genetic determinant of non-alcoholic fatty liver disease
f) immunity
g) extracellular vesicles

In the second module, the following topics will be discussed: overview of human-microbe interactions, antimicrobial compounds: mechanism of action and resistance, identifying novel conventional targets for antimicrobial discovery, and non-conventional targets for novel generation of antimicrobial compounds, challenges in novel antimicrobial compounds discovery.
Prerequisites for admission
Basic knowledge of anatomy, physiology, and microbiology
Teaching methods
Active lectures - standard teacher-based lessons
Teaching Resources
Scientific articles pertaining to topics covered throughout the course
Books that can help:
a) Pathological bases for precision medicine interventions (Robbins and Cotran).
b) Authors : Abul K. Abbas & Andrew H. Lichtman & Shiv Pillai; Cellular and Molecular Immunology, 10th Edition.

Other
a) Selected scientific materials (articles, websites) will be provided.
b) The lesson slides will be available on the Ariel website to the students (articles, websites) will be provided.
Assessment methods and Criteria
For the first module (Prof. Ruscica) the oral test will evaluate students' knowledge of the fundamental concepts of the subject. Positive marks range from 18 to 30; e.g., 18/30 (the lowest mark) or 30/ 30 cum laude (the highest mark).
BIO/19 - MICROBIOLOGY - University credits: 2
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 6
Lessons: 64 hours
Professor(s)
Reception:
Upon request
INGM, via Francesco Sforza 35, or DiSFeB, via Balzaretti 9, Milano
Reception:
Upon request
Department of Pharmacological and Biomolecular Sciences - Via Balzaretti 9 - Milano