Chemotherapy and Biological Drugs
A.Y. 2024/2025
Learning objectives
The course program includes the teaching of: 1) biochemical and pharmacological properties, production methods and clinical indications for biotechnological drugs; 2) mechanism of action, pharmacology and clinical toxicology of anti-infective, anti-tumor and immunoregulatory chemotherapeutics. The aim of the course is to provide the knowledge on the rational bases for the development and clinical use of these classes of drugs and to contribute to the formation of professionals with the cultural and practical skills necessary for the future occupational opportunities within the health area.
Expected learning outcomes
Students 1) know the mechanisms by which biotechnological and chemotherapeutic drugs act; 2) know the methodologies for the synthesis of biotechnological drugs; 3) are able to predict the pharmacodynamics and pharmacokinetics of biotechnological and chemotherapeutic drugs; 4) know the classes of drugs available for the different therapeutic areas; 5) are able to predict adverse reactions associated with the use of biotechnological and chemotherapeutic drugs
Lesson period: First semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course can be attended as a single course.
Course syllabus and organization
Linea AL
Responsible
Lesson period
First semester
Course syllabus
1. CHEMOTHERAPY OF MICROBIAL DISEASES
1.1 General principles of microbe biology
1.2 Chemotherapy of bacterial infections
1.3 Antiviral drugs for HIV, Influenza and COVID19
1.4 Vaccines and immune-mediated therapeutics
1.5 Antimicotic drugs
1.6 Clinical use: guidelines for the clinical use of antibiotics; antibiotic associations; antibiotic prophylaxis; mechanisms of resistance
2. BIOTECHNOLOGICAL DRUGS
2.1 Genetic engineering and pharmaceutical biotechnology in drug R&D
2.2 Recombinant proteins used in therapy: hormones, cytokines, blood proteins
2.3 Monoclonal antibodies and derivatives: generation and engeneering, clinical use
2.4 Fusion proteins
2.5 Nucleic acids as therapeutic agents
2.6 mRNA-based rugs
2.7 Advanced therapies; gene and cell therapies
2.8 Pharmacokinetics of biotechnological drugs
2.9 Pharmacogenetics and pharmacogenomics
3. CHEMOTHERAPY OF NEOPLASTIC DISEASES
3.1 Cytotoxic drugs: rational bases for clinical use; classical and novel drugs
3.2 Hormonal therapy in breast and prostate cancer
3.3 Target therapy; tyrosine kinase inhibitors
3.4 Immune therapy in cancer
4. IMMUNE MODULATORS
4.1 Immune suppressing agents
4.2 Immune stimulating agents
1.1 General principles of microbe biology
1.2 Chemotherapy of bacterial infections
1.3 Antiviral drugs for HIV, Influenza and COVID19
1.4 Vaccines and immune-mediated therapeutics
1.5 Antimicotic drugs
1.6 Clinical use: guidelines for the clinical use of antibiotics; antibiotic associations; antibiotic prophylaxis; mechanisms of resistance
2. BIOTECHNOLOGICAL DRUGS
2.1 Genetic engineering and pharmaceutical biotechnology in drug R&D
2.2 Recombinant proteins used in therapy: hormones, cytokines, blood proteins
2.3 Monoclonal antibodies and derivatives: generation and engeneering, clinical use
2.4 Fusion proteins
2.5 Nucleic acids as therapeutic agents
2.6 mRNA-based rugs
2.7 Advanced therapies; gene and cell therapies
2.8 Pharmacokinetics of biotechnological drugs
2.9 Pharmacogenetics and pharmacogenomics
3. CHEMOTHERAPY OF NEOPLASTIC DISEASES
3.1 Cytotoxic drugs: rational bases for clinical use; classical and novel drugs
3.2 Hormonal therapy in breast and prostate cancer
3.3 Target therapy; tyrosine kinase inhibitors
3.4 Immune therapy in cancer
4. IMMUNE MODULATORS
4.1 Immune suppressing agents
4.2 Immune stimulating agents
Prerequisites for admission
"Applied Microbiology and Hygiene" ("Microbiologia applicata ed Igiene") and "Pharmacology and Pharmacotherapy" ("Farmacologia e Farmacoterapia").
Teaching methods
Slides available on the MyAriel website. Recommended attendance.
Teaching Resources
FARMACI BIOTECNOLOGICI. Aspetti farmacologici e clinici dei medicinali biotecnologici
Vegeto E, Maggi A, Minghetti P
Ed. CEA-ZANICHELLI
Farmacologia Molecolare e Cellulare
Clementi E, Fumagalli G
Ed. EdiSES
Farmacologia generale e clinica
Katzung & Trevor,
Ed PICCIN
"Le basi farmacologiche della terapia
Goodman & Gillman
Ed. Zanichelli
Le basi biologiche e cliniche delle Malattie Infettive
Shulman et al
Ed. EdiSES
Vegeto E, Maggi A, Minghetti P
Ed. CEA-ZANICHELLI
Farmacologia Molecolare e Cellulare
Clementi E, Fumagalli G
Ed. EdiSES
Farmacologia generale e clinica
Katzung & Trevor,
Ed PICCIN
"Le basi farmacologiche della terapia
Goodman & Gillman
Ed. Zanichelli
Le basi biologiche e cliniche delle Malattie Infettive
Shulman et al
Ed. EdiSES
Assessment methods and Criteria
The exam will be an oral examination aimed at verifying the acquisition of knowledge on the topics covered in the course, using assessment criteria that include rational and narrative ability and critical reasoning.
Linea MZ
Responsible
Lesson period
First semester
In case of emergency, lessons will take place remotely using the MicrosoftTeams platform.
Course syllabus
1. CHEMOTHERAPY OF MICROBIAL DISEASES
1.1 General principles of antimicrobial therapy
1.2 Chemotherapy of bacterial infections
1.3 Treatment of HIV infection
1.4 Treatment of influenza
1.4.1 Coronavirus and drug therapies
2. BIOTECHNOLOGICAL DRUGS
2.1 Genetic engineering and pharmaceutical biotechnology
2.2 Recombinant proteins used in therapy
2.3 Fusion proteins
2.4 Monoclonal antibodies and derivatives
2.5 Fusion proteins
2.6 Nucleic acids as therapeutic agents
2.7 Advanced therapies
2.5 Pharmacokinetics of biotechnological drugs
3. CHEMOTHERAPY OF NEOPLASTIC DISEASES
3.1 Cytotoxic drugs
3.2 Target therapy
3.3 Immune therapy in cancer
3.4 Hormonal therapy in cancer
4. IMMUNE MODULATORS
4.1 Immune suppressing agents
3.2 Immune stimulating agents
1.1 General principles of antimicrobial therapy
1.2 Chemotherapy of bacterial infections
1.3 Treatment of HIV infection
1.4 Treatment of influenza
1.4.1 Coronavirus and drug therapies
2. BIOTECHNOLOGICAL DRUGS
2.1 Genetic engineering and pharmaceutical biotechnology
2.2 Recombinant proteins used in therapy
2.3 Fusion proteins
2.4 Monoclonal antibodies and derivatives
2.5 Fusion proteins
2.6 Nucleic acids as therapeutic agents
2.7 Advanced therapies
2.5 Pharmacokinetics of biotechnological drugs
3. CHEMOTHERAPY OF NEOPLASTIC DISEASES
3.1 Cytotoxic drugs
3.2 Target therapy
3.3 Immune therapy in cancer
3.4 Hormonal therapy in cancer
4. IMMUNE MODULATORS
4.1 Immune suppressing agents
3.2 Immune stimulating agents
Prerequisites for admission
"Applied Microbiology and Hygiene" ("Microbiologia applicata ed Igiene") and "Pharmacology and Pharmacotherapy" ("Farmacologia e Farmacoterapia").
Teaching methods
Slides available on the Ariel website
Teaching Resources
FARMACI BIOTECNOLOGICI. Aspetti farmacologici e clinici dei medicinali biotecnologici
Vegeto E, Maggi A, Minghetti P
Ed. CEA-ZANICHELLI
Farmacologia Molecolare e Cellulare
Clementi E, Fumagalli G
Ed. EdiSES
Farmacologia generale e clinica
Katzung & Trevor,
Ed PICCIN
"Le basi farmacologiche della terapia
Goodman & Gillman
Ed. Zanichelli
Le basi biologiche e cliniche delle Malattie Infettive
Shulman et al
Ed. EdiSES
Vegeto E, Maggi A, Minghetti P
Ed. CEA-ZANICHELLI
Farmacologia Molecolare e Cellulare
Clementi E, Fumagalli G
Ed. EdiSES
Farmacologia generale e clinica
Katzung & Trevor,
Ed PICCIN
"Le basi farmacologiche della terapia
Goodman & Gillman
Ed. Zanichelli
Le basi biologiche e cliniche delle Malattie Infettive
Shulman et al
Ed. EdiSES
Assessment methods and Criteria
The exam will be an oral examination aimed at verifying the acquisition of knowledge on the topics covered in the course, using assessment criteria that include rational and narrative ability and critical reasoning.
Professor(s)