Metabolic and Functional Biochemistry
A.Y. 2018/2019
Learning objectives
To acquire an "in-depth" and integrated view of metabolic pathways and molecular regulatory networks in organs and tissues in patho-physiology
To acquire an updated overview of the metabolic implications that have recently emerged in the field of tumoral proliferation, inflammation, development (stem cells) and aging
To acquire the ability to understand the biochemical background, the functional implications and the experimental approaches applied in metabolic studies that have been recently published in top journals
To acquire an updated overview of the metabolic implications that have recently emerged in the field of tumoral proliferation, inflammation, development (stem cells) and aging
To acquire the ability to understand the biochemical background, the functional implications and the experimental approaches applied in metabolic studies that have been recently published in top journals
Expected learning outcomes
Undefined
Lesson period: First semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Single session
Responsible
Lesson period
First semester
Course syllabus
The following topics will be addressed
Liver Structure of the hepatic lobule and its "zonation": metabolic aspects and regulatory networks. Biochemistry and regulation of the main metabolic pathways; glucose and fatty acid metabolism; amino acid metabolism and ammonia detoxification; mevalonate pathway; synthesis and metabolism of bile acids. Biochemical and bio-molecular features of biotransformations and of lipoprotein metabolism. Metabolic effects of xenobiotics (1.5 cfu)
Digestive tract Metabolic and functional features of gastro-intestinal cell types. Relationship linking microbiota, intestinal immune system and metabolism. Biochemistry of digestion (0.5 cfu)
Adipose tissues Molecular mechanisms underlying differentiation and metabolic functions of adipose tissues. Biochemistry, molecular mechanisms and regulatory networks underlying lipolysis and lipogenesis. Role of adipose tissue-derived factors on metabolic homeostasis (0.5 cfu)
Skeletal muscle and bone Metabolic features of myofibers; biochemical determinants and molecular mechanisms underlying myofiber remodeling. General structure and main components of bone; calcium metabolism; biochemistry and metabolic features of osteoblast and osteoclast differentiation and of bone remodeling. Role of bone-derived factors on metabolic homeostasis (0.5 cfu)
Brain Features and metabolic functions of neural cells; glucose metabolism in astrocytes and neurons; glutamate/glutamine metabolism in astrocytes and neurons; functional implications of cholesterol and fatty acid metabolism in the brain (0.5 cfu)
Metabolic networks Metabolic crosstalk among organs and tissues; metabolic homeostasis in response to hormones and in the fasted/fed state; molecular regulatory mechanisms underlying metabolic homeostasis; metabolic dysfunctions (0.5 cfu)
Biochemical-metabolic aspects associated to tumoral cell proliferation; inflammation; stem cells; and aging will be addressed (1.5 cfu)
Textbooks and other reference material
Lecture slide shows are generally made available as printed material and/or PowerPoint presentations that can be found at the teacher's web-site within the Ariel platform http://ariel.unimi.it
The pdf of articles discussed during the course and other relevant material can be downloaded by accessing the University Online Library (Sistema Bibliotecario di Ateneo) http://www.sba.unimi.it/ using the student's ID and password.
The following textbooks may be used as reference
Fondamenti di Biochimica, Voet, Voet & Pratt, Zanichelli
Principi di Biochimica con messa a fuoco su quella umana, Garret & Grisham, Piccin
Biochimica, Matthews, Van Holde, Ahern, Casa Editrice Ambrosiana
Biochimica, Berg, Tymoczko, Streyer, Zanichelli
I principi di biochimica di Lehninger, Nelson & Cox, Zanichelli
Biochimica Medica (IV edizione), Siliprandi & Tettamanti, Piccin
TESTS, REQUIREMENTS, PROPEDEUTIC COURSES
The learning assessment in based on an oral test. Students will be evaluated for their knowledge of the subjects presented during the course, for their ability to integrate different topics in a general metabolic overview. Core knowledge from the courses of Biochemistry and Molecular Biology is mandatory for a full understanding and learning of the subjects presented during the course.
Liver Structure of the hepatic lobule and its "zonation": metabolic aspects and regulatory networks. Biochemistry and regulation of the main metabolic pathways; glucose and fatty acid metabolism; amino acid metabolism and ammonia detoxification; mevalonate pathway; synthesis and metabolism of bile acids. Biochemical and bio-molecular features of biotransformations and of lipoprotein metabolism. Metabolic effects of xenobiotics (1.5 cfu)
Digestive tract Metabolic and functional features of gastro-intestinal cell types. Relationship linking microbiota, intestinal immune system and metabolism. Biochemistry of digestion (0.5 cfu)
Adipose tissues Molecular mechanisms underlying differentiation and metabolic functions of adipose tissues. Biochemistry, molecular mechanisms and regulatory networks underlying lipolysis and lipogenesis. Role of adipose tissue-derived factors on metabolic homeostasis (0.5 cfu)
Skeletal muscle and bone Metabolic features of myofibers; biochemical determinants and molecular mechanisms underlying myofiber remodeling. General structure and main components of bone; calcium metabolism; biochemistry and metabolic features of osteoblast and osteoclast differentiation and of bone remodeling. Role of bone-derived factors on metabolic homeostasis (0.5 cfu)
Brain Features and metabolic functions of neural cells; glucose metabolism in astrocytes and neurons; glutamate/glutamine metabolism in astrocytes and neurons; functional implications of cholesterol and fatty acid metabolism in the brain (0.5 cfu)
Metabolic networks Metabolic crosstalk among organs and tissues; metabolic homeostasis in response to hormones and in the fasted/fed state; molecular regulatory mechanisms underlying metabolic homeostasis; metabolic dysfunctions (0.5 cfu)
Biochemical-metabolic aspects associated to tumoral cell proliferation; inflammation; stem cells; and aging will be addressed (1.5 cfu)
Textbooks and other reference material
Lecture slide shows are generally made available as printed material and/or PowerPoint presentations that can be found at the teacher's web-site within the Ariel platform http://ariel.unimi.it
The pdf of articles discussed during the course and other relevant material can be downloaded by accessing the University Online Library (Sistema Bibliotecario di Ateneo) http://www.sba.unimi.it/ using the student's ID and password.
The following textbooks may be used as reference
Fondamenti di Biochimica, Voet, Voet & Pratt, Zanichelli
Principi di Biochimica con messa a fuoco su quella umana, Garret & Grisham, Piccin
Biochimica, Matthews, Van Holde, Ahern, Casa Editrice Ambrosiana
Biochimica, Berg, Tymoczko, Streyer, Zanichelli
I principi di biochimica di Lehninger, Nelson & Cox, Zanichelli
Biochimica Medica (IV edizione), Siliprandi & Tettamanti, Piccin
TESTS, REQUIREMENTS, PROPEDEUTIC COURSES
The learning assessment in based on an oral test. Students will be evaluated for their knowledge of the subjects presented during the course, for their ability to integrate different topics in a general metabolic overview. Core knowledge from the courses of Biochemistry and Molecular Biology is mandatory for a full understanding and learning of the subjects presented during the course.
BIO/10 - BIOCHEMISTRY - University credits: 6
Lessons: 48 hours
Professor:
De Fabiani Emma Selina Rosa
Professor(s)
Reception:
Mondays, Wednesdays, and Fridays from 4:00 p.m. to 5:00 p.m. and upon request via Microsoft Teams or email
Microsoft Teams