High-Throughput Molecular, Etiopathogenetic and Therapeutic Approach for the Study of Microcirculation Dysfunctions

Microcirculation dysfunction is a key element in cardio/cerebro/vascular and metabolic diseases, but also inflammatory and degenerative diseases, including mechanisms of alteration of hemostasis, immunity and endothelium. The altered intercellular communication between endothelium, blood cells and coagulation factors plays an important role in the functionality of the microcirculation and subsequently vascular damage compromises the diffusion of oxygen and metabolites resulting in organ failure and mortality. The aim of the course is to introduce the student to a new paradigm of translational medicine based on the definition of biomolecular signatures thanks to the integration of omics, bioinformatics and bio-engineering analyses to identify pathways that help in understanding the mechanisms underlying human disease. This will lead to an understanding of the molecular and clinical stratification of patients with microcirculation dysfunction for a future precision medicine with targeted diagnosis, prognosis and therapies.