Functional Genomics and the Molecular Basis of Differentiation

The course "Functional genomics and the molecular basis of differentiation" aims to provide students with a solid theoretical and practical knowledge of the study of microbial communities, genome sequencing and annotation, and phylogenetic relationship among organisms. Furthermore, the course offers information and training on recent advances in understanding the molecular basis of genomic and epigenetic mechanisms in regulating gene expression in livestock species.

1. Knowledge and understanding: By the end of the course, students are expected to have acquired an in-depth understanding of the main methods used in the study of bacterial genomes, a general overview of metagenomic and metatranscriptomic analyses, and practical skills in gene analysis, sequence alignment and comparison, the use of major biological databases, and phylogenetic reconstruction. In addition, students will acquire knowledge of DNA epigenetics changes and their effects on gene regulation and cell differentiation. Furthermore, students will gain a detailed overview of the new techniques applied to epigenetic profiling and acquire expertise on the ENCODE database.
2. Applying knowledge and understanding: Students must demonstrate fundamental theoretical and conceptual knowledge of the principal methods used in genome analysis (including genome sequencing techniques, genome annotation, and phylogenetic studies), as well as skill in bioinformatics tools used to study genomes and interactions between organisms. Furthermore, students must demonstrate knowledge of epigenetics, gene expression, and genome variation.
3. Making judgments: Students must demonstrate the ability to critically and thoughtfully discuss the knowledge they have acquired. To this end, specific in-class exercises and individual activities are planned. Furthermore, students are expected to show that they have developed the skills necessary to engage with the teacher on topics related to interactions between organisms and their biological mechanisms, as well as epigenetics and functional genomics.
4. Communication: Students must demonstrate the ability to communicate using scientifically appropriate terminology and to apply the most suitable bioinformatics tools for the analysis of genomes, interactions among organisms, and topics related to livestock epigenetics and functional genomics.
5. Lifelong learning skills: The student's ability to pursue independent study will be supported through continuous interaction with the teacher, who will enhance the learning experience by drawing on scientific publications, online resources, audiovisual content, and other digital materials. These tools are intended to provide an integrated perspective on the opportunities available in both industrial settings and research institutions, guiding students toward the informed and conscious application of the knowledge acquired. Bioinformatics activities will furthermore strengthen students' practical learning skills.