Toxicology
A.Y. 2024/2025
Learning objectives
- Characterize the manifestation and mechanisms of toxicity
- Provide scientific basis for experimental toxicology and criteria for evaluating and extrapolating toxicity data to humans
- Provide adequate toxicological knowledge and valid bases for defining the criteria for protecting human health from the risks deriving from the direct (drugs, food additives, etc.) or indirect exposure (environmental pollutants, industrial solvents, etc.) of substances (chemical and biological).
- Provide scientific basis for experimental toxicology and criteria for evaluating and extrapolating toxicity data to humans
- Provide adequate toxicological knowledge and valid bases for defining the criteria for protecting human health from the risks deriving from the direct (drugs, food additives, etc.) or indirect exposure (environmental pollutants, industrial solvents, etc.) of substances (chemical and biological).
Expected learning outcomes
Knowledge and understanding of the main aspects of toxicology with particular reference to general and organ toxicity of xenobiotics
Lesson period: Second semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course can be attended as a single course.
Course syllabus and organization
Linea AK
Responsible
Lesson period
Second semester
Course syllabus
PRINCIPLES AND METHODS
- Principles of general toxicology: definition of hazard and risk, the concept of dose, the areas of toxicology-from molecular mechanisms to laws through risk assessment, classes of toxic agents, dose-response curves and relevance to toxic effect, Molecule-target interaction and related effects, concept of reversibility and irreversibility, dose-effect relationships, acute, subacute, subchronic, chronic toxicity, factors influencing toxicity
- Mechanisms of Toxicity: Oxidative damage, Mitochondrial toxicity, Calcium homeostasis, Mechanisms of protection and repair
GENERAL TOXICOLOGY
- Teratogenesis
- Mutagenesis
- Carcinogenesis
ORGAN TOXICOLOGY
- Respiratory toxicology
- Immunotoxicology
- Nervous System Toxicology
- Renal Toxicology
- Hepatic Toxicology
- Cutaneous Toxicology
- Ocular Toxicology
TOXICITY OF CHEMICAL AND PHYSICAL AGENTS
- Pesticides
- Solvents
- Radioactivity
- Metals
- Natural toxins
RISK ASSESSMENT
- Risk assessment
° Ecotoxicology
° Pharmacovigilance
EMERGING TOPICS
° Novel Food
° Animal testing and legislation
- Principles of general toxicology: definition of hazard and risk, the concept of dose, the areas of toxicology-from molecular mechanisms to laws through risk assessment, classes of toxic agents, dose-response curves and relevance to toxic effect, Molecule-target interaction and related effects, concept of reversibility and irreversibility, dose-effect relationships, acute, subacute, subchronic, chronic toxicity, factors influencing toxicity
- Mechanisms of Toxicity: Oxidative damage, Mitochondrial toxicity, Calcium homeostasis, Mechanisms of protection and repair
GENERAL TOXICOLOGY
- Teratogenesis
- Mutagenesis
- Carcinogenesis
ORGAN TOXICOLOGY
- Respiratory toxicology
- Immunotoxicology
- Nervous System Toxicology
- Renal Toxicology
- Hepatic Toxicology
- Cutaneous Toxicology
- Ocular Toxicology
TOXICITY OF CHEMICAL AND PHYSICAL AGENTS
- Pesticides
- Solvents
- Radioactivity
- Metals
- Natural toxins
RISK ASSESSMENT
- Risk assessment
° Ecotoxicology
° Pharmacovigilance
EMERGING TOPICS
° Novel Food
° Animal testing and legislation
Prerequisites for admission
Knowledge of basic human anatomy and principles of biology
Teaching methods
The course is conducted through lectures and in-class discussion of the syllabus.
The material relating to the lectures delivered can be found on the Ariel Unimi web page dedicated to the course.
The material relating to the lectures delivered can be found on the Ariel Unimi web page dedicated to the course.
Teaching Resources
· Tossicologia, Galli-Corsini-Marinovich, editore PICCIN, 2 Edizione (2008)
· Casarett & Doull's -Tossicologia, Ed. Curtis D.Klaassen, 5° edizione (vers. italiana) EMSI - Roma
· Tossicologia cellulare e molecolare, Ed. G. Cantelli Forti, P. Hrelia, C.L.Galli, M. Marinovich, UTET (2000)
· Casarett & Doull's -Toxicology, The basic science of poisons, Fifth edition (1999), Ed. C.D. Klaassen , J.B. Watkins III°, McGraw Hill
· General & Applied Toxicology, Ed. B. Ballantyne, T. Marrs, P. Turner, MacMillan Press
· Casarett & Doull's -Tossicologia, Ed. Curtis D.Klaassen, 5° edizione (vers. italiana) EMSI - Roma
· Tossicologia cellulare e molecolare, Ed. G. Cantelli Forti, P. Hrelia, C.L.Galli, M. Marinovich, UTET (2000)
· Casarett & Doull's -Toxicology, The basic science of poisons, Fifth edition (1999), Ed. C.D. Klaassen , J.B. Watkins III°, McGraw Hill
· General & Applied Toxicology, Ed. B. Ballantyne, T. Marrs, P. Turner, MacMillan Press
Assessment methods and Criteria
The aim of the course is to provide a basic knowledge of the principles of toxicology through the characterisation of the main mechanisms of toxicity, both at the cellular and organ level, and through the mechanisms of different classes of chemicals. The acquisition of these competences will be assessed independently by two different professors through an oral examination on any topic of the programme. The final mark out of thirty will be the average of the marks given by each professor.
BIO/14 - PHARMACOLOGY - University credits: 8
Lessons: 64 hours
Professor:
Viviani Barbara
Shifts:
Turno
Professor:
Viviani BarbaraLinea LZ
Responsible
Lesson period
Second semester
Course syllabus
GENERAL PRINCIPLES OF TOXICOLOGY
· Principles of Toxicology
· Mechanisms of Toxicity
· Methods of in vitro toxicology
NON-ORGAN-DIRECTED TOXICITY
· Developmental toxicology
· Genetic toxicology
· Carcinogenesis
TARGET ORGAN TOXICITY
· Toxic responses of the respiratory system
· Toxic responses of the immune system
· Toxic responses of the Nervous System
· Toxic responses of the kidney
· Toxic responses of the liver
· Toxic responses of eye
CHEMICAL AND PHYSICAL AGENTS TOXICITY
· Pesticides
· solvents
· radioactivity
· Metals
· Natural Toxins
° nanotoxicology
Hints of Ecotoxicology, Pharmacovigilance, Animal Welfare in research
RISK ASSESSMENT
· Risk assessment
· Principles of Toxicology
· Mechanisms of Toxicity
· Methods of in vitro toxicology
NON-ORGAN-DIRECTED TOXICITY
· Developmental toxicology
· Genetic toxicology
· Carcinogenesis
TARGET ORGAN TOXICITY
· Toxic responses of the respiratory system
· Toxic responses of the immune system
· Toxic responses of the Nervous System
· Toxic responses of the kidney
· Toxic responses of the liver
· Toxic responses of eye
CHEMICAL AND PHYSICAL AGENTS TOXICITY
· Pesticides
· solvents
· radioactivity
· Metals
· Natural Toxins
° nanotoxicology
Hints of Ecotoxicology, Pharmacovigilance, Animal Welfare in research
RISK ASSESSMENT
· Risk assessment
Prerequisites for admission
The teachings of Human Anatomy and General Biology are propaedeutic.
Teaching methods
The lessons will be held in person. Slides will be available on the Ariel page.
Teaching Resources
· Tossicologia, Galli-Corsini-Marinovich, editore PICCIN, 2 Edizione (2008)
· Casarett & Doull's -Tossicologia, Ed. Curtis D.Klaassen, 5° edizione (vers. italiana) EMSI - Roma
· Tossicologia cellulare e molecolare, Ed. G. Cantelli Forti, P. Hrelia, C.L.Galli, M. Marinovich, UTET (2000)
· Casarett & Doull's -Toxicology, The basic science of poisons, Fifth edition (1999), Ed. C.D. Klaassen , J.B. Watkins III°, McGraw Hill
· General & Applied Toxicology, Ed. B. Ballantyne, T. Marrs, P. Turner, MacMillan Press
· Casarett & Doull's -Tossicologia, Ed. Curtis D.Klaassen, 5° edizione (vers. italiana) EMSI - Roma
· Tossicologia cellulare e molecolare, Ed. G. Cantelli Forti, P. Hrelia, C.L.Galli, M. Marinovich, UTET (2000)
· Casarett & Doull's -Toxicology, The basic science of poisons, Fifth edition (1999), Ed. C.D. Klaassen , J.B. Watkins III°, McGraw Hill
· General & Applied Toxicology, Ed. B. Ballantyne, T. Marrs, P. Turner, MacMillan Press
Assessment methods and Criteria
The exam consists of a face-to-face interview aimed at assessing the acquisition and skill in toxicology
BIO/14 - PHARMACOLOGY - University credits: 8
Lessons: 64 hours
Professor:
Marinovich Marina
Shifts:
Turno
Professor:
Marinovich MarinaProfessor(s)
Reception:
by appointment
Dip. di Scienze Farmacologiche, Via Balzaretti 9