Physiopathology, Introduction in Biotechnologies Diagnostic and Therapy
A.Y. 2024/2025
Learning objectives
The training course has the following aims:
- Comprehension of the main physiological systems and their related pathophysiology
- Comprehension of the principles of diagnostic and therapy in liquids and solids tumors
- Comprehension of the main physiological systems and their related pathophysiology
- Comprehension of the principles of diagnostic and therapy in liquids and solids tumors
Expected learning outcomes
The course aims to provide students with the basic knowledge of the major human diseases and the processes that cause them, in order to provide the necessary background for understanding the role of the biotechnology tools employed in diagnostics and therapy of these alterations. To this end, the course is structured in a series of lectures regarding the pathophysiology of the main systems complemented by lectures on the possible biotechnological approaches related to the diagnostics and treatment of the analyzed diseases.
Lesson period: First semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course can be attended as a single course.
Course syllabus and organization
Single session
Responsible
Lesson period
First semester
Prerequisites for admission
Students must have fulfilled all the prerequisite requirements indicated in the study plan: Biochemistry and Fundamentals of Human Biochemistry, General Pathology and Immunology, Human phyisiology.
Assessment methods and Criteria
Verification of learning takes place through a written test. Reference materials are not allowed during the learning verification. The test results are sent electronically by the President of the Integrated Course of Clinical Sciences. The final mark represents the weighted average of the individual modules and will be expressed in 30/30.
Medical physiopathology
Course syllabus
Pathophysiology of the Nervous System and neurodegenerative diseases
Pathophysiology of the Cardiovascular System:
The heart as a pump, Heart failure
Ischemic heart disease
The Hypertension
The vascular occlusive disease
Pathophysiology of the Respiratory System:
The acute respiratory failure
The chronic respiratory failure
Pathophysiology of the Endocrine:
Role of biotechnology in the management of endocrine tumors (oncogenes and tumor suppressor);
Premature ovarian failure: menopausal age prediction and tools for fertility preservation;
Pathophysiology of GnRH neuron: molecular diagnostics and fertility biotech drugs;
Sensitivity problems and promiscuity hormonal action
Pathophysiology of kidney: Acute renal failure and chronic
Pathophysiology of the liver: acute hepatitis, chronic hepatitis, cirrhosis. NAFLD, NASH.
Pathophysiology of the Hematopoietic System:
Hematopoiesis
Anemia
Iron metabolism and related conditions
Thalassemia
Pathophysiology of the Cardiovascular System:
The heart as a pump, Heart failure
Ischemic heart disease
The Hypertension
The vascular occlusive disease
Pathophysiology of the Respiratory System:
The acute respiratory failure
The chronic respiratory failure
Pathophysiology of the Endocrine:
Role of biotechnology in the management of endocrine tumors (oncogenes and tumor suppressor);
Premature ovarian failure: menopausal age prediction and tools for fertility preservation;
Pathophysiology of GnRH neuron: molecular diagnostics and fertility biotech drugs;
Sensitivity problems and promiscuity hormonal action
Pathophysiology of kidney: Acute renal failure and chronic
Pathophysiology of the liver: acute hepatitis, chronic hepatitis, cirrhosis. NAFLD, NASH.
Pathophysiology of the Hematopoietic System:
Hematopoiesis
Anemia
Iron metabolism and related conditions
Thalassemia
Teaching methods
Teaching takes place through lectures with slide projections.
Teaching Resources
Nuovo Manuale di Ematologia" di P. Corradini e R. Foà - Dic 2014, edizioni Minerva Medica.
Principles of diagnostic and biotechnological therapy
Course syllabus
Principles of diagnostics and therapy in hematology:
Hematopoiesis and its diagnostics
New methods to study tumor transformation in hematology
Haemostasis and Thrombosis
The hematopoietic stem cell
Myeloproliferative diseases
Lymphoproliferative diseases
Plasma cells disorders
Concepts of hematopoietic stem cell transplantation
Minimal residual disease in onco-hematology: methods and applications;
Molecular therapy in hematology: new drugs and monoclonal antibodies;
Outline of methodology in clinical research
Principles of diagnostics and therapy in oncology:
Principles of tumour biology: mechanisms of neoplastic transformation
Epidemiology of solid tumours
Principles of medical oncology therapy: clinical classification and staging of solid tumours: intent of therapy, adverse events and outcome measures; cytotoxic chemotherapy; molecular targeted drugs; immunotherapy.
Interpretation of clinical trial results.
Applications of molecular pathology to cancer therapy: biomarkers; liquid biopsy.
Hematopoiesis and its diagnostics
New methods to study tumor transformation in hematology
Haemostasis and Thrombosis
The hematopoietic stem cell
Myeloproliferative diseases
Lymphoproliferative diseases
Plasma cells disorders
Concepts of hematopoietic stem cell transplantation
Minimal residual disease in onco-hematology: methods and applications;
Molecular therapy in hematology: new drugs and monoclonal antibodies;
Outline of methodology in clinical research
Principles of diagnostics and therapy in oncology:
Principles of tumour biology: mechanisms of neoplastic transformation
Epidemiology of solid tumours
Principles of medical oncology therapy: clinical classification and staging of solid tumours: intent of therapy, adverse events and outcome measures; cytotoxic chemotherapy; molecular targeted drugs; immunotherapy.
Interpretation of clinical trial results.
Applications of molecular pathology to cancer therapy: biomarkers; liquid biopsy.
Teaching methods
Teaching takes place through lectures with slide projections.
Teaching Resources
Nuovo Manuale di Ematologia" di P. Corradini e R. Foà - Dic 2014, edizioni Minerva Medica.
Medical physiopathology
MED/09 - INTERNAL MEDICINE
MED/13 - ENDOCRINOLOGY AND METABOLISM
MED/15 - BLOOD DISEASES
MED/13 - ENDOCRINOLOGY AND METABOLISM
MED/15 - BLOOD DISEASES
Informal teaching: 16 hours
Lessons: 32 hours
Lessons: 32 hours
Professors:
Bonomi Marco, Cirello Valentina, Corradini Paolo, Guidetti Anna, Motta Irene, Persani Luca
Shifts:
Turno
Professors:
Bonomi Marco, Cirello Valentina, Corradini Paolo, Guidetti Anna, Motta Irene, Persani Luca
Principles of diagnostic and biotechnological therapy
MED/06 - MEDICAL ONCOLOGY
MED/18 - GENERAL SURGERY
MED/26 - NEUROLOGY
MED/18 - GENERAL SURGERY
MED/26 - NEUROLOGY
Informal teaching: 8 hours
Lessons: 28 hours
Lessons: 28 hours
Shifts:
Professor(s)
Reception:
Friday 14-15 (appointment requested)
IRCCS Istituto Auxologico Italiano - Ospedale San Luca (5°piano) - Piazzale Brescia 20 - 20149 Milano
Reception:
appointment to be agreed by e-mail
Reception:
To be arranged by email
ASST Grande Ospedale Metropolitano Niguarda, Blocco Sud