Physiopathology, Introduction in Biotechnologies Diagnostic and Therapy

A.Y. 2024/2025

Max ECTS

Overall hours

SSD

MED/06 MED/09 MED/13 MED/15 MED/18 MED/26

Language

Italian

Included in the following degree programmes

Medical Biotechnology (Classe L-2)-Enrolled from 2014/15 Academic Year

Learning objectives

The training course has the following aims:
- Comprehension of the main physiological systems and their related pathophysiology
- Comprehension of the principles of diagnostic and therapy in liquids and solids tumors

Expected learning outcomes

The course aims to provide students with the basic knowledge of the major human diseases and the processes that cause them, in order to provide the necessary background for understanding the role of the biotechnology tools employed in diagnostics and therapy of these alterations. To this end, the course is structured in a series of lectures regarding the pathophysiology of the main systems complemented by lectures on the possible biotechnological approaches related to the diagnostics and treatment of the analyzed diseases.

Lesson period: First semester

Lessons timetable

Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi

Exams calendar

Single course

This course can be attended as a single course.

Take a single course

Course syllabus and organization

Single session

Responsible

Corradini Paolo

Lesson period

First semester

Syllabus

Prerequisites for admission

Students must have fulfilled all the prerequisite requirements indicated in the study plan: Biochemistry and Fundamentals of Human Biochemistry, General Pathology and Immunology, Human phyisiology.

Assessment methods and Criteria

Verification of learning takes place through a written test. Reference materials are not allowed during the learning verification. The test results are sent electronically by the President of the Integrated Course of Clinical Sciences. The final mark represents the weighted average of the individual modules and will be expressed in 30/30.

Medical physiopathology

Course syllabus

Pathophysiology of the Nervous System and neurodegenerative diseases
Pathophysiology of the Cardiovascular System:
The heart as a pump, Heart failure
Ischemic heart disease
The Hypertension
The vascular occlusive disease
Pathophysiology of the Respiratory System:
The acute respiratory failure
The chronic respiratory failure
Pathophysiology of the Endocrine:
Role of biotechnology in the management of endocrine tumors (oncogenes and tumor suppressor);
Premature ovarian failure: menopausal age prediction and tools for fertility preservation;
Pathophysiology of GnRH neuron: molecular diagnostics and fertility biotech drugs;
Sensitivity problems and promiscuity hormonal action
Pathophysiology of kidney: Acute renal failure and chronic
Pathophysiology of the liver: acute hepatitis, chronic hepatitis, cirrhosis. NAFLD, NASH.
Pathophysiology of the Hematopoietic System:
Hematopoiesis
Anemia
Iron metabolism and related conditions
Thalassemia

Teaching methods

Teaching takes place through lectures with slide projections.

Teaching Resources

Nuovo Manuale di Ematologia" di P. Corradini e R. Foà - Dic 2014, edizioni Minerva Medica.

Principles of diagnostic and biotechnological therapy

Course syllabus

Principles of diagnostics and therapy in hematology:
Hematopoiesis and its diagnostics
New methods to study tumor transformation in hematology
Haemostasis and Thrombosis
The hematopoietic stem cell
Myeloproliferative diseases
Lymphoproliferative diseases
Plasma cells disorders
Concepts of hematopoietic stem cell transplantation
Minimal residual disease in onco-hematology: methods and applications;
Molecular therapy in hematology: new drugs and monoclonal antibodies;
Outline of methodology in clinical research

Principles of diagnostics and therapy in oncology:
Principles of tumour biology: mechanisms of neoplastic transformation
Epidemiology of solid tumours
Principles of medical oncology therapy: clinical classification and staging of solid tumours: intent of therapy, adverse events and outcome measures; cytotoxic chemotherapy; molecular targeted drugs; immunotherapy.
Interpretation of clinical trial results.
Applications of molecular pathology to cancer therapy: biomarkers; liquid biopsy.

Teaching methods

Teaching takes place through lectures with slide projections.

Teaching Resources

Nuovo Manuale di Ematologia" di P. Corradini e R. Foà - Dic 2014, edizioni Minerva Medica.

Course structure

Medical physiopathology

MED/09 - INTERNAL MEDICINE
MED/13 - ENDOCRINOLOGY AND METABOLISM
MED/15 - BLOOD DISEASES

Informal teaching: 16 hours
Lessons: 32 hours

Professors: Bonomi Marco, Cirello Valentina, Corradini Paolo, Guidetti Anna, Motta Irene, Persani Luca

Shifts:

Turno

Professors: Bonomi Marco, Cirello Valentina, Corradini Paolo, Guidetti Anna, Motta Irene, Persani Luca