Pathology
A.Y. 2024/2025
Learning objectives
We will study causes and mechanisms of disease. To this end, we will examine the molecular, cellular and functional effects due to the occurrence of pathogenic events (such as genetic alterations, activation of cellular oncogenes). We will study cell damage, death, adaptation, and the systemic and local reaction to tissue damage, with an in depth analysis of the inflammatory reaction.
Expected learning outcomes
The student will acquire the knowledge tools to understand the fundamental causes of disease mechanisms, with dual focus on general aspects and on molecular mechanisms. She/he will learn the molecular, cellular and functional aspects at the basis of altered cellular states which lead to disease, including cancer.
Lesson period: First semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course can be attended as a single course.
Course syllabus and organization
Single session
Responsible
Lesson period
First semester
Course syllabus
Molecular and cellular aspects of cell damage:
-Apoptosis, necrosis and other types of cell death
-Autophagy
-Cell and organismal aging
Genetic bases of disease
Inflammation and related diseases
Cancer:
-introduction, taxonomy and epidemiology
-cancer etiology, heredity and environment, cancer cell properties
-tumor genetic heterogeneity, concepts of genomics and transcriptomics, precision medicine
-cancer stem cells and cancer plasticity
-metastasis, angiogenesis and tumor microenvironment
-cancer immunotherapy
-Apoptosis, necrosis and other types of cell death
-Autophagy
-Cell and organismal aging
Genetic bases of disease
Inflammation and related diseases
Cancer:
-introduction, taxonomy and epidemiology
-cancer etiology, heredity and environment, cancer cell properties
-tumor genetic heterogeneity, concepts of genomics and transcriptomics, precision medicine
-cancer stem cells and cancer plasticity
-metastasis, angiogenesis and tumor microenvironment
-cancer immunotherapy
Prerequisites for admission
None
Teaching methods
Teacher's lessons supported by slides and open discussion.
Teaching Resources
Slides of the lessons will be made available on Ariel/MS Teams.
Suggested texts (not mandatory):
- Pontieri et al. Patologia generale e fisiopatologia generale - Volume 1
- Moncharmont et al. Patologia generale - Volume 1.
Suggested texts (not mandatory):
- Pontieri et al. Patologia generale e fisiopatologia generale - Volume 1
- Moncharmont et al. Patologia generale - Volume 1.
Assessment methods and Criteria
Oral exams (Open questions on the course topics). Students attending the lessons and volunteering for the auxiliary test can prepare two written reports on topics selected by the teacher. Such auxillary test will weigh for 66% of final evaluation. Final mark will be given as score out of 30.
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 6
Lessons: 48 hours
Professor:
Gandellini Paolo
Professor(s)
Reception:
to be agreed by e-mail
Dept. Biosciences, floor 7, tower B