Organ Pathophysiology

A.Y. 2024/2025
6
Max ECTS
48
Overall hours
SSD
MED/04
Language
Italian
Learning objectives
The course is designed to present essential concepts of pathological processes and altered health states. Thus, the main objective is to study the pathological mechanisms beyond the systemic diseases paying special attention to the etiology (cause of the disease) and the pathogenesis (origin and development of a disease). The fields covered will be: atherosclerosis, cardiocirculatory system, neurodegenerative diseases, thyroid, diabetes mellitus, liver, microbiota and immune system.
Brief summary:
1. Classification of systemic and organ specific diseases and how they manifest clinically.
2. Identification of abnormal physiologic conditions causing the disease.
3. Study of the etiology and pathogenesis of diseases, with the final goal to identify specific pathways that can be targeted by biotechnological approaches.
Expected learning outcomes
Identification of the different etiologies and pathogenetic mechanism correlated to the pathological processes: atherosclerosis, cardiocirculatory system, neurodegenerative diseases, thyroid, diabetes mellitus, liver and microbiota.
Ability to translate the theoretical approach to a more practical one. To pursue this object, the students will face with recent research articles which have addressed the mechanisms beyond the pathologies studied.
To acquire the ability to relate these essential basic pathological processes to the pathogenesis of common and important diseases.
To correlate clinical features with the causes and mechanisms of disease.
Single course

This course can be attended as a single course.

Course syllabus and organization

Single session

Responsible
Lesson period
First semester
Course syllabus
Liver-related diseases and related comorbidities
- Hepatitis
- Genetic determinants of non-alcoholic fatty liver disease
- Metabolic syndrome - Obesity
- Diabetes (type 1, type 2, gestational)
- Atherosclerosis
- Thrombosis and coagulation
- Myocardial infarction (Electrocardiogram (EKG)) and classification
- Impact of environmental pollution in cardiovascular field
- Hypertension
- Thyroid
- Prions
- Anemia and blood related diseases
- Immunity system: innate and acquired immunity; inflammatory processes
Prerequisites for admission
Anatomy and physiology: endocrine system, cardiovascular system, lymphatic system. The heart, the liver, the thyroid, the pancreas, the gastrointestinal tract, the brain
Teaching methods
Active lectures - standard teacher-based lessons
Teaching Resources
(1) All the slide are present on Ariel webpage
(2) Patologia Generale e Fisiopatologia, Fabio Celotti, 2013. Edises
(3) Robbins. Fondamenti di patologia e di fisiopatologia di Vinay Kumar, Abul K. Abbas, J. C. Aster
(4) Robbins and Cotran; Pathological bases for precision medicine interventions
(5) Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai: Immunologia cellulare e molecolare. Elsevier Ed
Assessment methods and Criteria
Oral test to evaluate students' knowledge of the fundamental concepts of the subject. Positive marks range from 18 to 30; e.g., 18/30 (the lowest mark) or 30/ 30 cum laude (the highest mark).
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 6
Lessons: 48 hours
Professor(s)