Medicinal and Toxicological Chemistry Ii

The course aims at providing the most relevant concepts related to the design, synthesis, physicochemical and stereo-electronic properties, mechanism of action, therapeutic application and side effects of the drugs belonging to the investigated classes. Lectures will deal with the structure-activity relationships and the approaches applied in medicinal chemistry to optimize the pharmacodynamic profile and the pharmacokinetic properties of drugs. Based on the fundamentals acquired in the lessons of Medicinal and Toxicological Chemistry I, in the present course the student should accomplish a good overall background in medicinal chemistry, through the study of drugs acting on the central and peripheral nervous system, the cardiovascular and antihistamine drugs, and the non-steroidal anti-inflammatory agents.

Knowledge and understanding. The course aims to ascertaining the student's knowledge of the approaches and methods presented during the lectures, particularly those related to the structural aspects of drugs, their genesis, and their therapeutic classification.
Applying knowledge and understanding. During the exam, the student should be able to apply knowledge and understanding by appropriately discussing the main aspects of the structure/synthesis of the main compounds of a class of drugs, together with their related therapeutic utility.
Making judgements. The student will answer any question with pertinence and criticism, both in the written and oral part of the exam. Students are frequently requested to motivate their own choices in the answers.
Communication. During the exam, the student will demonstrate to explain and develop concepts with clarity, synthesis, and language skills. Clarity of presentation and communication skills are part of the overall evaluation.