Fundamentals of Clinical Medicine 3

A.Y. 2024/2025
11
Max ECTS
132
Overall hours
SSD
M-EDF/01 MED/12 MED/13 MED/35
Language
English
Learning objectives
The course is designed to address, with systematic approach the pathophysiology and diseases of the endocrine and gastrointestinal systems, as well as to dermatology and venereology and to introduce students to exercise and sport medicine. The endocrinology module is designed to teach the students the appropriate skills to understand the origins of and diagnose patients with endocrine disorders, to interpret endocrine and hormonal tests and manage both acute and chronic conditions. The gastroenterology module addresses disorders and diseases of the Gastrointestinal Tract, including the Liver and the Pancreas with a systematic approach and is designed to make students familiar with clinical presentation and differential diagnosis of GI diseases. The Exercise and Sport Medicine Module provides the students with conceptual tools to introduce lifestyle intervention programs (with particular focus on physical exercise and nutrition) to foster health/wellbeing and to prevent/treat major chronic non communicable diseases. The dermatology module will enable students to diagnose common skin diseases and understand the principles of the therapeutic management of these patients. The course will cover the pathogenesis of the main skin conditions and the main therapies to use including both topical preparations and systemic drugs, such as immunomodulating agents, immunosuppressants and biologics.
Expected learning outcomes
Students are expected to: - identify the typical and atypical features of endocrine disorders, their presentation, clinical course and expected outcome. - interpret endocrine tests and manage acute and chronic conditions. - describe aetiologies, pathogenetic mechanisms, morphological changes of neoplastic proliferations of the pituitary gland, thyroid gland, parathyroid glands and adrenal gland - describe pathological classification and prognostic markers of the neuroendocrine tumors. -describe aetiologies, pathogenetic mechanisms and morphological changes of non-neoplastic diseases of the endocrine system. - interpret endocrine tests and manage acute and chronic conditions. -identify the typical and atypical features of gastrointestinal disorders, their presentation, differential diagnosis, clinical course and expected outcome. -describe aetiologies, pathogenetic mechanisms and morphological changes of non-neoplastic diseases of the gastrointestinal tract -describe the aetiologies, pathogenetic mechanisms, morphological changes, prognostic and predictive factors of esophageal, gastric and intestinal tumors. - describe the pathological changes of the liver in hepatitis and cirrhosis and tumors and tumor-like lesions. -describe the pathological changes of the inflammatory and neoplastic conditions of the pancreas. -
Students will learn -the definitions, the differences and the clinical importance of the Exercise and Sport Medicine, the definition of Health, Wellbeing, Prevention and Lifestyle Medicine - the effects of lifestyle interventions on main etiopathogenetic mechanisms of chronic non communicable diseases: a translational approach, - the importance of exercise medicine in chronic non communicable disease (cardiometabolic diseases, cancer, functional syndromes, etc), the cardiometabolic risk and lifestyle assessment, - the patient's assessment in order to prescribe lifestyle intervention programs (with particular focus on physical exercise and nutrition), - the definition of specific clinical goals and personalized medicine in lifestyle interventions, -the exercise prescription, -the nutrition program prescription, - the synergies between exercise and nutrition programs
Students will also learn: -to acquire an understanding of the scientific basis of dermatology; -to relate knowledge of skin structure to the physical signs of skin disease; -to take a coherent dermatological history and be able to describe cutaneous physical signs using appropriate terminology; -To recognise common skin diseases; -to recognise important cutaneous signs of systemic disease or adverse reactions to drugs; -To understand the principles of dermatological treatment.
Single course

This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.

Course syllabus and organization

Single session

Responsible
Prerequisites for admission
To take the Fundamentals of Clinical Medicine 3 exam, students must have already passed all the exams of the first year (Fundamentals of Basic Sciences, Cells, Molecules and Genes , Histology, Anatomy, Biochemistry, Fundamentals of biomedical imaging) and all the exams of second years (Functions 1 and 2, Microbiology, Genetics and Mechanisms of diseases).
Assessment methods and Criteria
Students will be assessed through an oral examination on all 4 modules of the course. Examinations on two consecutive days are seldom possible depending upon the availability of teachers or rooms.
The final mark is the average of the marks obtained in the 4 disciplines: endocrinology, gastroenterology, exercise and sport medicine and dermatology weighted for the number of credits in each discipline.
The examination is deemed passed if the mark for each of the 4 disciplines is 18/30 or higher. In the event of a full grade (30/30) honors (lode) may be granted with the consent of all the professors.
Attendance is required to be allowed to take the exam. Unexcused absence is tolerated up to 34% of the course activities. University policy regarding excused illness is followed. Registration to the exam through SIFA is mandatory.
Gastroenterology
Course syllabus
GASTROENTEROLOGY: the gastroenterology module addresses disorders and diseases of the Gastrointestinal Tract, including the Liver and the Pancreas. This will be obtained by means of lectures covering, in a systematic approach, all disease states from pathophysiology to clinical presentation and diagnostic work-up; these topics will also be covered by problem-based sessions and case studies, to make students familiar with clinical presentation and differential diagnosis of GI diseases.
Session 1. GASTROENTEROLOGY: Course Presentation & Frontier Lecture
Introduction to the Course
Physical examination of the abdomen
Frontier Lecture: The GALT and the microbiome: from "physiological" inflammation to disease and therapy
Session 2. GASTROENTEROLOGY: System Diseases: Esophagus
Esophageal function
Motor disorders of the esophagus
Gastroesophageal reflux disease
Esophageal structure, Barrett's esophagus and esophageal tumors
Eosinophilic Esophagitis
Imaging of the esophagus
Session 3. GASTROENTEROLOGY: Approach to the patient with dysphagia and gastric symptoms
Dysphagia: the diagnostic flow-chart
Dyspepsia, Nausea and Vomiting
Case discussion
Session 5. GASTROENTEROLOGY: System Diseases: Stomach and Duodenum
Gastric function
Helicobacter Pylori Infection & its clinical relates
Peptic Ulcer Disease and its complications
Gastric Adenocarcinoma and Other Tumors of the Stomach
Session 6. GASTROENTEROLOGY: Approach to Patients with GI bleeding
Hematemesis, melena, hematochezia, occult bleeding
Diagnostic work-up and Case Discussion
Session 7. Pathology of the stomach
Acute and chronic gastritis: etiologies, pathogenic mechanisms and morphological changes
Pathogenic mechanisms and pathological changes of peptic ulcer disease
Epidemiology, risks factors and pathogenic mechanisms of gastric cancer
Classification, morphologic changes, prognostic and predictive parameters of gastric adenocarcinoma
Gastrointestinal stromal tumors
Lymphoid neoplasms of the stomach
Session 8. GASTROENTEROLOGY, System Diseases: Pancreas
Pancreatic function
Acute pancreatitis -
Chronic pancreatitis and pancreatic insufficiency
Pancreatic adenocarcinoma, cystic and neuroendocrine neoplasms of the pancreas -
Case discussion
Session 9. PATHOLOGY: Pathology of the pancreas
Acute and Chronic Pancreatitis: morphological changes.
Pancreatic neoplasms: histological classification, morphological changes, prognostic factors.
Session 10. GASTROENTEROLOGY: Approach to the patient with Liver disease
Laboratory tests and imaging interpretation in clinical practice
Diagnostic flow chart in jaundice
Case discussion
Session 11. GASTROENTEROLOGY: Liver diseases due to infectious Agents
Hepatitis Virus from A to D and beyond: clinical features and outcomes
Case discussion
Session 12. GASTROENTEROLOGY: Clinical consequences of Liver diseases
Cirrhosis and its complications, portal hypertension and Hepatocellular Carcinoma
Case discussion
Session 13. GASTROENTEROLOGY: System Diseases: Immune mediated Liver diseases
Autoimmune Hepatitis
Primary Biliary Cholangitis
Primary Sclerosing Cholangitis
Differential diagnosis, imaging
Case discussion
Session 14. GASTROENTEROLOGY: System Diseases: Inherited liver diseases
Hemochromatosis
Wilson disease
Case discussion
Session 15. GASTROENTEROLOGY: Metabolic and toxic liver diseases
Drug-induced hepatotoxicity
Alcoholic hepatitis
NASH, NAFLD
Case discussion
Session 16. GASTROENTEROLOGYDiseases of the biliary tract
Gallstones: diagnosis, natural history and complications
Session 18 GASTROENTEROLOGY: System Diseases: Small and Large Intestine - Part 1
Celiac Disease and Other Malabsorption Syndromes
Infectious causes of diarrhea and malabsorption - clinical
Irritable Bowel Syndrome
Case discussion
Laboratory tests
Session 19. GASTROENTEROLOGY: Frontier Lecture/Seminar: Intestinal epithelium: a multifunctional machinery
Session 20. GASTROENTEROLOGY: Approach to the patients with chronic diarrhea
Diagnostic flow-chart of chronic diarrhea
Case discussion
Teaching methods
Synchronous learning: lectures, Clinical cases, Seminars, Grand Rounds, Case studies and Laboratory skills.
Asynchronous learning: audio-video based (pre-recorded, multimedia platforms); text-based (e-mail, electronic documents, discussion boards, blogs); mixed (virtual libraries, social networks)
All teaching materials (files of the teaching presentations and/or recorded lectures) will be made available on a specific Ariel platform.
Teaching Resources
Harrison's Principles of Internal Medicine, 21th Edition, McGraw Hill, 2022 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/
Endotext: The best Clinical Endocrinology source in the world, and FREE. (www.endotext.org)
Sleisenger And Fordtran's Gastrointestinal And Liver Disease, 10th edition
Endocrinology
Course syllabus
MODULE: ENDOCRINOLOGY AND METABOLISM
GENERAL OVERVIEW:
The endocrinology module is designed to teach the students the appropriate skills to diagnose patients with endocrine disorders. The students will also learn to identify the typical and atypical features of endocrine disorders, their presentation, clinical course and expected outcome. The students will also improve their ability to interpret endocrine tests and manage acute and chronic conditions.

Topic 1 - ENDOCRINOLOGY: Impact of endocrinology on general health
Overview of hormonal axes involved in homeostasis and their regulation
Feedback mechanisms
Stress response
General mechanisms of endocrine diseases
Epidemiology of the main endocrine diseases
Topic 2 - ENDOCRINOLOGY: Hypothalamus and Pituitary
Hypothalamus and pituitary
Pituitary/hypothalamic lesions (Non-functioning adenomas, Prolactinomas and Somatotropinomas/acromegaly/ craniopharyngioma) and correlated syndromes (pathogenesis, diagnosis, clinical manifestations, and management)
Topic 3 - ENDOCRINOLOGY: Hypothalamus and pituitary: hypopituitarism
Causes of (pan)hypopituitarism
Diagnosis, clinical manifestations, and management of (pan)hypopituitarism
Water balance disorders
Topic 4 - ENDOCRINOLOGY: Thyroid function and hypothyroidism
Thyroid gland follicles: origin and function
Thyroid hormone action and regulation
Testing of thyroid function
Causes of hypothyroidism, autoimmune thyroiditis
Clinical manifestations
Diagnosis and management
Thyroid and fertility/pregnancy
Topic 5 - ENDOCRINOLOGY: Thyroid dysfunction: hyperthyroidism
Causes of hyperthyroidism/thyrotoxicosis
Clinical manifestations, including orbitopathy
Subacute and post-partum thyroiditis
Diagnosis and management
Topic 6 - ENDOCRINOLOGY: Diagnostic problems of thyroid conditions and rare thyroid diseases
Diagnostic problems in hypo- and hyperthyroidism
Resistance to thyroid hormone and TSH-secreting adenomas
Topic 7 - ENDOCRINOLOGY: Thyroid goiter, nodules and cancers
Iodide deficiency and goiter
Clinical manifestations of nodular goiter and cancers
Diagnosis and management of nodular goiter and cancers
Topic 8 - ENDOCRINOLOGY: Obesity, disorders of lipid metabolism and nutrition disorders
Epidemiology
Classification
Diabesity and metabolic syndrome
Metabolic and cardiovascular consequences
Urbanization, lifestyle changes and metabolic diseases
Bariatric surgery
Topic 9 - ENDOCRINOLOGY: Diabetes Mellitus type 1 and 2
Epidemiology
Classification
Diagnosis and management
Complications (comas, nephropathy, etc)
Gestational diabetes
Topic 10 - ENDOCRINOLOGY: Hypoglycemia and differential diagnosis
Epidemiology
Classification
Diagnosis and management
Topic 11 - ENDOCRINOLOGY: Male reproductive endocrinology
Puberty: mechanisms and sex differences
Delayed puberty in males
Klinefelter syndrome and hypogonadotropic hypogonadism: diagnosis, clinical manifestations, and management
Late onset hypogonadism: diagnosis, clinical manifestations, and management
Topic 12 - ENDOCRINOLOGY: Female reproductive endocrinology
Primary and secondary amenorrhea, Turner syndrome and Primary Ovarian Insufficiency: diagnosis, clinical manifestations, and management
Hirsutism and Polycystic Ovary Syndrome (PCOS): diagnosis, clinical manifestations, and management
Topic 13 - ENDOCRINOLOGY: Adrenal function and diseases
Adrenal function: physiology
Hypercorticolism
Cushing disease vs syndrome and pseudocushing: diagnosis, clinical manifestations, and management
Endocrine hypertension (pheochromocytoma, primary hyperaldosteronism)
Addison disease and 21-hydroxylase deficiency
Determination of steroid hormones
Topic 14 - ENDOCRINOLOGY: Disorders of calcium homeostatsis
Parathyroid gland and vitamin D
Hypercalcemia and Hyperparathyroidism: clinical manifestations, diagnosis and management
Hypocalcemia and Hypoparathyroidism: clinical manifestations, diagnosis and management
How to test vitamin D, PTH, and calcemia
Topic 15 - ENDOCRINOLOGY Multiple Endocrine Neoplasia and neuroendocrine tumors
MEN1: pathogenesis, clinical manifestations, diagnosis and management
MEN2: pathogenesis, clinical manifestations, diagnosis and management
Topic 16: ENDOCRINOLOGY: Metabolic Bone disorders
Primary and secondary osteoporosis: pathogenesis, clinical manifestations, diagnosis and management
ENDOCRINOLOGY: Interactive clinical case discussion
Problem solving (group study and preparation)
Role playing
Interactive discussions
Teaching methods
Synchronous learning: lectures, Clinical cases, Seminars, Grand Rounds, Case studies and Laboratory skills.
Asynchronous learning: audio-video based (pre-recorded, multimedia platforms); text-based (e-mail, electronic documents, discussion boards, blogs); mixed (virtual libraries, social networks)
All teaching materials (files of the teaching presentations and/or recorded lectures) will be made available on a specific Ariel platform.
Teaching Resources
HANDBOOK of Endocrinology and Metabolism, Eds: Luca Persani, Olaf Hiort, Mario Maggi, Alberto M. Pereira; Edizioni Minerva Medica (2024)
Harrison's Principles of Internal Medicine, 21th Edition, McGraw Hill, 2022 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/
Dermatology
Course syllabus
MODULE DERMATOLOGY
GENERAL OVERVIEW
DERMATOLOGY: the dermatology module course will introduce students to the study of dermatology and venereology, enabling them to diagnose the most common skin diseases and understand the principles of therapeutic management of the dermatological patient
Topic n1 - Introduction to Dermatology: anatomy and functional areas
Topic n2 - Skin Biochemistry
Topic n3 - Physiology of the skin
Topic n4 - Skin care
Topic n5 - Topical Therapy Principles
Topic n6 - Skin Infectious Diseases - parasitic and mycotic
Topic n7 - Skin Infectious Diseases - bacterial and viral
Topic n8 - Skin Allergic Diseases
Topic n9 - Skin Inflammatory Diseases
Topic n10 - Skin Reactive Diseases
Topic n11 - OncoDermatology 1
Topic n12 - OncoDermatology 2
Topic n13 - Autoinflammatory diseases
Topic n14 - Viral exanthemas 1
Topic n15 - Viral exanthemas 2
Topic n16 - Drug induced reactions
Topic n17 - Hidradenitis suppurativa
Topic n18 - Cutaneous manifestations associated with COVID-19
Teaching methods
Synchronous learning: lectures, Clinical cases, Seminars, Grand Rounds, Case studies and Laboratory skills.
Asynchronous learning: audio-video based (pre-recorded, multimedia platforms); text-based (e-mail, electronic documents, discussion boards, blogs); mixed (virtual libraries, social networks)
All teaching materials (files of the teaching presentations and/or recorded lectures) will be made available on a specific Ariel platform.
Teaching Resources
Ayala F, Lisi P, Monfrecola G, Argenziano G, Stingeni L. Malattie cutanee e veneree. Seconda Edizione, Piccin 2019
Fisical training sciences and methodology
Course syllabus
GENERAL OVERVIEW:
EXERCISE AND SPORT MEDICINE the exercise and sport medicine will provide the students with conceptual tools to introduce lifestyle intervention programs (with particular focus on physical exercise and nutrition) to foster health/wellbeing and to prevent/treat major chronic non communicable diseases
·Achievement of a beginner's level of the understanding of how the principal etiopathogenetic mechanisms of chronic non communicable diseases are modified by lifestyle interventions
·Achievement of the basic clinical competencies in order to define cardio-metabolic risk and behaviors
·Acquisition of the most important competencies to prescribe lifestyle intervention programs (with particular focus on physical exercise and nutrition) in order to foster health/wellbeing and to prevent/treat major chronic non communicable diseases.
·Acquisition of the core competencies to motivate subjects/patients to modify their lifestyle
·Achievement of a beginner's level of the understanding of etiopathogenetic mechanisms of stress and functional syndromes and acquisition of the basic competencies to manage these conditions particularly using lifestyle modification programs

TOPICS:
TOPIC 1: From cardiometabolic risk to lifestyle management to prevent/treat chronic non-communicable diseases
TOPIC 2: Principles of behavioural medicine to improve lifestyle: from "what" to "how"
TOPIC 3: Exercise physiology and its clinical importance
TOPIC 4: Prescription of exercise program
TOPIC 5: Prescription of nutrition program
TOPIC 6: Lifestyle, Stress and Functional Syndromes
TOPIC 7: Sport Medicine: assessment and clinical management of athletes
TOPIC 8: Stop smoking: pharmacological and behavioural approaches
TOPIC 9: clinical case: fibromyalgia and diabetes
TOPIC 10: clinical case: psoriasis and irritable bowel syndromes
TOPIC 11: clinical case: breast cancer and osteoporosis
TOPIC12: clinical case: stress syndrome and obesity
Teaching methods
Synchronous learning: lectures, Clinical cases, Seminars, Grand Rounds, Case studies and Laboratory skills.
Asynchronous learning: audio-video based (pre-recorded, multimedia platforms); text-based (e-mail, electronic documents, discussion boards, blogs); mixed (virtual libraries, social networks)
All teaching materials (files of the teaching presentations and/or recorded lectures) will be made available on a specific Ariel platform.
Teaching Resources
ACSM's Guidelines for Exercise Testing and Prescription. 2018, 10th ed
Dermatology
MED/35 - DERMATOLOGY AND VENEREAL DISEASES - University credits: 3
Lessons: 24 hours
: 12 hours
Shifts:
Endocrinology
MED/13 - ENDOCRINOLOGY AND METABOLISM - University credits: 3
Lessons: 24 hours
: 12 hours
Fisical training sciences and methodology
M-EDF/01 - PHYSICAL TRAINING SCIENCES AND METHODOLOGY - University credits: 2
Lessons: 16 hours
: 8 hours
Professor: Lucini Daniela
Shifts:
Turno
Professor: Lucini Daniela
Gastroenterology
MED/12 - GASTROENTEROLOGY - University credits: 3
Lessons: 24 hours
: 12 hours
Professor(s)
Reception:
Friday 14-15 (appointment requested)
IRCCS Istituto Auxologico Italiano - Ospedale San Luca (5°piano) - Piazzale Brescia 20 - 20149 Milano
Reception:
Monday and Friday 9-10 AM
Niguarda Hospital, Piazza Ospedale Maggiore 3, 20162, Milan; Blocco Nord, III Floor, Room N 14
Reception:
On appointment (send an email)
Exercise Medicine Units, IRCCS Istituto Auxologico Italiano, via Pier Lombardo 22
Reception:
Send an e-mail to schedule an appointment
San Paolo Hospital - Block A, Third floor, room 38 - Via Di Rudinì 8, Milan