Cellular and Molecular Pathology
A.Y. 2024/2025
Learning objectives
To perform an in-depth cellular and molecular analysis of the bases of disease. Selected topics (see below) will be the subject of study, and presentation of recent articles will follow a general introduction for each of them.
Expected learning outcomes
At the end of the course, the student will know and understand the cell and molecular mechanisms underpinning the major pathological processes and will have the bases to autonomously develop research projects aimed at identifying novel pathogenetic mechanisms and developing new potential therapeutic strategies. The student will be also competent in reading and critically analyzing scientific articles in the field, as well as in communicating scientific data through slide-assisted oral presentations.
Lesson period: Second semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course can be attended as a single course.
Course syllabus and organization
Single session
Responsible
Lesson period
Second semester
Course syllabus
· Genomic approaches in cancer
· Noncoding RNA and cancer
· Autophagy and pharmacological approaches
· Senescence, Ageing and modulation of senescence
· Telomere maintenance mechanisms and their targeting
· Cancer metastasis, epithelial-mesenchymal transition, circulating tumor cells and the liquid biopsy
· Tumor microenvironment: cancer-associated fibroblasts, tumor-associated macrophages and extracellular vesicles
· Tumor cell plasticity, cancer stem cells and drug resistance
· Caloric restriction: role in ageing and therapy
· Trained immunity
· Immune system, cancer and immunotherapy
· Sex disparity in cancer
· Noncoding RNA and cancer
· Autophagy and pharmacological approaches
· Senescence, Ageing and modulation of senescence
· Telomere maintenance mechanisms and their targeting
· Cancer metastasis, epithelial-mesenchymal transition, circulating tumor cells and the liquid biopsy
· Tumor microenvironment: cancer-associated fibroblasts, tumor-associated macrophages and extracellular vesicles
· Tumor cell plasticity, cancer stem cells and drug resistance
· Caloric restriction: role in ageing and therapy
· Trained immunity
· Immune system, cancer and immunotherapy
· Sex disparity in cancer
Prerequisites for admission
None.
Teaching methods
Teacher's lessons supported by slides. Discussion of scientific articles regarding the program topics in groups of students, assisted by the teacher.
Teaching Resources
All materials (slides of the lessons, presentations, articles) will be made available on Ariel/MS Teams.
Assessment methods and Criteria
Oral exams (Open questions on the course topics) to evaluate acquired knowledge and understanding on the topic. Students will have the opportunity to present, on a voluntary basis, one or more articles regarding the program topics during the ordinary lessons, with the help of the teacher. If choosing this option (and limited to the current academic year), evaluation of this activity will consist of 75% of total evaluation at the final exam. Final mark will be given as score out of 30.
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 6
Lessons: 48 hours
Professor:
Gandellini Paolo
Professor(s)
Reception:
to be agreed by e-mail
Dept. Biosciences, floor 7, tower B