Medical Pharmacology (3rd year)
A.Y. 2022/2023
Learning objectives
The course aims to provide students with an advanced knowledge of:
i) the drug mechanism of action at molecular, cellular and organ/apparatus level;
ii) the main pharmacokinetic parameters and their clinical significance;
iii) factors influencing the drug response in relation with the pharmacologic interactions and individual features;
iv) the available drugs for different therapeutic areas, their side-effects and pharmacologic interactions;
v) the criteria for the rational choice among different drugs available for a specific therapeutic area.
i) the drug mechanism of action at molecular, cellular and organ/apparatus level;
ii) the main pharmacokinetic parameters and their clinical significance;
iii) factors influencing the drug response in relation with the pharmacologic interactions and individual features;
iv) the available drugs for different therapeutic areas, their side-effects and pharmacologic interactions;
v) the criteria for the rational choice among different drugs available for a specific therapeutic area.
Expected learning outcomes
Students:
a) know the fundamental mechanisms of drug action;
b) are able to apply the main pharmacokinetic parameters in the clinical practice;
c) are able to evaluate the influence of individual factors and pharmacological interactions in the therapy;
d) know the available drugs for different therapeutic areas, their potential side-effects and interactions in the polytherapy regimen;
e) are able to make a rational choice among different drugs available for a certain pharmacological therapy.
a) know the fundamental mechanisms of drug action;
b) are able to apply the main pharmacokinetic parameters in the clinical practice;
c) are able to evaluate the influence of individual factors and pharmacological interactions in the therapy;
d) know the available drugs for different therapeutic areas, their potential side-effects and interactions in the polytherapy regimen;
e) are able to make a rational choice among different drugs available for a certain pharmacological therapy.
Lesson period: Second semester
Assessment methods: Esame alla fine del gruppo
Assessment result: Inserire codice AF
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Single session
Responsible
Course syllabus
GENERAL PHARMACOLOGY - 36 hours 3rd year II semester -
1. Genera principles and molecular mechanism of drug action
2. Variability in drug responses
3. Quantitative aspects of drug action
4. Pharmacokinetics and Pharmacodynamics
5. Route of administration and pharmaceutical formulations
6. Mechanism of drug diffusion across biological membranes
7. Absorption and interfering factors
8. Drug distribution and tissue uptake
9. Drug metabolism, enzyme inhibitors or inducers
10. Drug excretion
11. Bioavailability, Volume of distribution, half-life and clearance: clinical significance
12. Pharmacologic interactions
13. Drug adverse reactions
14. Genetic basis of variability in drug
15. Personalized medicine
16. Generic drugs
17. Biologics and biosimilars
18. Clinical and preclinical drug development
19. The clinical trial phases: design, features, end points
20. Regulatory agency, role of ethical committees and references legislation
21. Pharmacovigilance and adverse reaction reports
22. Overview on the neurotransmission of the autonomic nervous system
PHARMACOLOGICAL MODULATION OF THE CARDIOVASCULAR SYSTEM 12 hours 3rd year II semester - Prof. Paolo Ciana
1. Antihypertensive drugs
2. Diuretics and ACE-inhibitors
3. Drugs treatment for heart failure
4. Antianginal drugs
5. Anticoagulants and anti-thrombotic drugs
6. Drugs treatment for heart attack
7. Lipid-lowering agents
8. Antiarrhythmic drugs
1. Genera principles and molecular mechanism of drug action
2. Variability in drug responses
3. Quantitative aspects of drug action
4. Pharmacokinetics and Pharmacodynamics
5. Route of administration and pharmaceutical formulations
6. Mechanism of drug diffusion across biological membranes
7. Absorption and interfering factors
8. Drug distribution and tissue uptake
9. Drug metabolism, enzyme inhibitors or inducers
10. Drug excretion
11. Bioavailability, Volume of distribution, half-life and clearance: clinical significance
12. Pharmacologic interactions
13. Drug adverse reactions
14. Genetic basis of variability in drug
15. Personalized medicine
16. Generic drugs
17. Biologics and biosimilars
18. Clinical and preclinical drug development
19. The clinical trial phases: design, features, end points
20. Regulatory agency, role of ethical committees and references legislation
21. Pharmacovigilance and adverse reaction reports
22. Overview on the neurotransmission of the autonomic nervous system
PHARMACOLOGICAL MODULATION OF THE CARDIOVASCULAR SYSTEM 12 hours 3rd year II semester - Prof. Paolo Ciana
1. Antihypertensive drugs
2. Diuretics and ACE-inhibitors
3. Drugs treatment for heart failure
4. Antianginal drugs
5. Anticoagulants and anti-thrombotic drugs
6. Drugs treatment for heart attack
7. Lipid-lowering agents
8. Antiarrhythmic drugs
Prerequisites for admission
The student should have acquired Biochemistry, Physiology, and Pathology basic knowledge to understand at molecular, cellular and systemic levels the mechanism of action, therapeutic indications and potential side-effects of drugs.
Teaching methods
The program will be carried out through lectures (10CFU) with the help of teaching material (slides)
Teaching Resources
Rang HP, Dale MM, Ritter JM, Flower RJ, Henderson G, "Farmacologia", Casa Editrice Elsevier
Goodman & Gilman, "Le basi farmacologiche della terapia", McGraw Hill, Farmacologia generale e clinica Bertram G. Katzung VIII edizione italiana
Goodman & Gilman, "Le basi farmacologiche della terapia", McGraw Hill, Farmacologia generale e clinica Bertram G. Katzung VIII edizione italiana
Assessment methods and Criteria
The course is divided into three academic years (3th, 4th and 5th); the student can choose among the following examination modalities:
1) At the end of each year, there will be an in itinere partial test and the final mark will be the weighted (based on the credits of each part) average of the marks acquired in the three exams. The exam consists in an oral exam on the programme of the year that will allow to evaluate the student's exposure abilities in the description of the therapeutic rationale, mechanism of action, side-effects and potential interactions of the drugs.
2) Alternatively, the student may choose a single final examination on the entire 3-years programme, at the end of the 5th year which consists in an oral exam that will allow to evaluate the student's exposure abilities in the description of the therapeutic rationale, mechanism of action, side-effects and potential interactions of the drugs.
Passing the test will result in a mark expressed in thirtieths.
1) At the end of each year, there will be an in itinere partial test and the final mark will be the weighted (based on the credits of each part) average of the marks acquired in the three exams. The exam consists in an oral exam on the programme of the year that will allow to evaluate the student's exposure abilities in the description of the therapeutic rationale, mechanism of action, side-effects and potential interactions of the drugs.
2) Alternatively, the student may choose a single final examination on the entire 3-years programme, at the end of the 5th year which consists in an oral exam that will allow to evaluate the student's exposure abilities in the description of the therapeutic rationale, mechanism of action, side-effects and potential interactions of the drugs.
Passing the test will result in a mark expressed in thirtieths.
Educational website(s)
Professor(s)
Reception:
Friday 10:00-12:30 a.m.
Department of Health Sciences, Via Antonio di Rudinì 8